(R)-CR8 trihydrochloride - ≥99%(HPLC), high purity , CAS No.1786438-30-9

Item Number

R287772

Grouped product items
SKU	Size	Availability	Price	Qty
R287772-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90
R287772-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$459.90

Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue

Basic Description

Specifications & Purity	≥99%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Product description (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K.

Names and Identifiers

IUPAC Name	(2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol;trihydrochloride
INCHI	InChI=1S/C24H29N7O.3ClH/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20;;;/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30);3*1H/t19-;;;/m1.../s1
InChi Key	ORYSYXHQFOWNDK-RGFWRHHQSA-N
Canonical SMILES	CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4.Cl.Cl.Cl
Isomeric SMILES	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4.Cl.Cl.Cl
PubChem CID	90488866
Molecular Weight	540.92

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
D2308445	Certificate of Analysis	Feb 20, 2023	R287772
D2308446	Certificate of Analysis	Feb 20, 2023	R287772

Solubility

Solvent:water, Max Conc. mg/mL: 54.09, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 54.09, Max Conc. mM: 100

Sensitivity

Moisture sensitive.

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Basic Description