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R(+)-IAA-94 - ≥98%, high purity , CAS No.54197-31-8

  • ≥98%
Item Number
I345659
Grouped product items
SKUSizeAvailabilityPrice Qty
I345659-2mg
2mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
I345659-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
I345659-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$179.90
I345659-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$339.90

a potent indanyloxyacetic acid blocker of epithelial chloride channels

View related series
Chloride Channel

Basic Description

SynonymsR(+)-IAA-94|IAA-94|54197-31-8|R(+)-Methylindazone|(S)-2-((6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)acetic acid|53108-01-3|CBiol_001794|2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid|CHEBI:34
Specifications & Purity≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

IAA-94 is an indanyloxyacetic acid blocker of epithelial chloride channels. IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins.

Product Properties

pKapKa: 2.80
Ki Datamammalian skeletal muscle and epithelial chloride channel: Ki= 1 μM (bovine kidney cortex microsomes)

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SNCA Tchem Alpha-synuclein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid
INCHI InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m0/s1
InChi Key RNOJGTHBMJBOSP-KRWDZBQOSA-N
Canonical SMILES CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3
Isomeric SMILES C[C@]1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3
WGK Germany 3
PubChem CID 656717
Molecular Weight 357.23

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/ml), ethanol (20 mg/ml), water (0.2 mg/ml), and 0.1 M NaOH (2.8 mg/ml). Insoluble in dilute aqueous acid:.
Refractive Indexn20D1.60 (Predicted)
Specific Rotation[α]α22/D +36.4°, c = 0.86 in methanol
Boil Point(°C)~537.2° C at 760 mmHg (Predicted)
Melt Point(°C)74-76° C

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators