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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I345659-2mg | 2mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
I345659-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $109.90 | |
I345659-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $179.90 | |
I345659-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $339.90 |
a potent indanyloxyacetic acid blocker of epithelial chloride channels
Synonyms | R(+)-IAA-94|IAA-94|54197-31-8|R(+)-Methylindazone|(S)-2-((6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)acetic acid|53108-01-3|CBiol_001794|2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid|CHEBI:34 |
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Specifications & Purity | ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Product Description | IAA-94 is an indanyloxyacetic acid blocker of epithelial chloride channels. IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. |
pKa | pKa: 2.80 |
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Ki Data | mammalian skeletal muscle and epithelial chloride channel: Ki= 1 μM (bovine kidney cortex microsomes) |
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IUPAC Name | 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid |
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INCHI | InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m0/s1 |
InChi Key | RNOJGTHBMJBOSP-KRWDZBQOSA-N |
Canonical SMILES | CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3 |
Isomeric SMILES | C[C@]1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3 |
WGK Germany | 3 |
PubChem CID | 656717 |
Molecular Weight | 357.23 |
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Solubility | Soluble in DMSO (25 mg/ml), ethanol (20 mg/ml), water (0.2 mg/ml), and 0.1 M NaOH (2.8 mg/ml). Insoluble in dilute aqueous acid:. |
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Refractive Index | n20D1.60 (Predicted) |
Specific Rotation[α] | α22/D +36.4°, c = 0.86 in methanol |
Boil Point(°C) | ~537.2° C at 760 mmHg (Predicted) |
Melt Point(°C) | 74-76° C |
WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |