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（R,S）-CHPG - ≥98%, high purity , CAS No.170846-74-9, Agonist of mGlu 5 receptor

Moligand™
≥98%

CAS#: 170846-74-9
Formula: C₈H₈NO₃Cl
Molecular Weight: 201.61
PubChem CID: 3645780

Item Number

C275617

Grouped product items
SKU	Size	Availability	Price
C275617-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$116.90
C275617-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$262.90
C275617-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$489.90

Selective mGlu 5 agonist

View related series

mGlu5 receptor Agonist

Basic Description

Synonyms	CHPG\|170846-74-9\|2-chloro-5-hydroxyphenylglycine\|2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid\|(RS)-2-Chloro-5-hydroxyphenylglycine\|chlorohydroxyphenylglycine\|LSA5YS5PNZ\|CHEMBL345498\|CHPG cpd\|UNII-LSA5YS5PNZ\|C8H8NO3Cl\|alpha-Amino-2-chloro-5-hydroxybenze
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Selective mGlu 5 receptor agonist.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of mGlu 5 receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Describtion: CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A5 Tchem Neutral amino acid transporter B(0) 0 Activities

Discover Target: SLC1A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 1 Activities

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
INCHI	InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
InChi Key	UNIDAFCQFPGYJJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1O)C(C(=O)O)N)Cl
Isomeric SMILES	C1=CC(=C(C=C1O)C(C(=O)O)N)Cl
PubChem CID	3645780
Molecular Weight	201.61

PubChem CID

ChEMBL Ligand

BindingDB Ligand

Wikipedia

CAS Registry No.

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
J2325183	Certificate of Analysis	Aug 19, 2024	C275617
J2325184	Certificate of Analysis	Aug 19, 2024	C275617
J2325185	Certificate of Analysis	Aug 19, 2024	C275617

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Le Duigou C & Kullmann DM. (2011) Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons.. J Neurosci, 31 (15): (5777-81). [PMID:21490219]
2. Besheer J et al.. (2009) Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens.. J Neurosci, 29 (30): (9582-91). [PMID:19641121]
3. Fontanez-Nuin DE et al.. (2011) Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons.. Cereb Cortex, 21 (3): (727-35). [PMID:20705895]

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