| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| R420385-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $120.90 |
| Synonyms | 1025687-58-4 | Fostamatinib disodium | R788 disodium | R 788 sodium | Fostamatinib disodium anhydrous | R788 (Fostamatinib) Disodium | R 935788 sodium | UNII-X9417132K8 | R788 SODIUM ANHYDROUS | R935788 (Fostamatinib disodium, R788) | R788 disodium (Fostamatinib) | X9417132K8 | |
|---|---|
| Specifications & Purity | 2mM in DMSO |
| Biochemical and Physiological Mechanisms | R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses a |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. |
| IUPAC Name | disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate |
|---|---|
| INCHI | InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2 |
| InChi Key | HSYBQXDGYCYSGA-UHFFFAOYSA-L |
| Canonical SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] |
| Isomeric SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] |
| PubChem CID | 25008120 |
| Molecular Weight | 624.42 |
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| Sensitivity | Moisture sensitive |
|---|---|
| Melt Point(°C) | >191°C (dec.) |
