rac O-Desmethyl venlafaxine β-D-glucuronide

Item Number

R352524

• Synonyms: o-Desmethylvenlafaxine-glucuronide | 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenyl beta-D-Glucopyranosiduronic Acid | rac O-Desmethyl venlafaxine beta -D-glucuronide | 1021933-98-1 | UNII-68PDXVEFMN | DTXSID601343443 | beta-D-Glucopyranosiduron
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice

Product Description

rac O-Desmethyl Venlafaxine β-D-Glucuronide is a metabolite of Venlafaxine . Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.