| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| R335956-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $332.90 |
a trizolopyrazine dipeptidyl peptidase IV inhibitor
| Storage Temp | Store at 2-8°C |
|---|---|
| Shipped In | Wet ice |
| Product Description | Rac-Sitagliptin is a CD26 (trizolopyrazine dipeptidyl peptidase IV, DPP-4) inhibitor. DPP-4 is an enzyme which breaks down incretins such as GLP-1, GIP, and gastrointestinal hormones. rac-Sitagliptin controls the release of insulin by inhibiting these gastrointestinal hormones via inhibiting CD26 (DPP-4). Alternate studies indicate that rac-Sitagliptin can induce hemolysis. Furthermore, rac-Sitagliptin increases the number of insulin-positive β-cells in islets by reducing apoptosis. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one |
|---|---|
| INCHI | InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2 |
| InChi Key | MFFMDFFZMYYVKS-UHFFFAOYSA-N |
| Canonical SMILES | C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N |
| Isomeric SMILES | C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N |
| PubChem CID | 11306691 |
| Molecular Weight | 407.31 |
Enter Lot Number to search for COA:
| Solubility | Soluble in Dichloromethane, Ethyl Acetate and Methanol |
|---|
| Pictogram(s) | GHS08, GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H318:Causes serious eye damage |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
