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rac-Sitagliptin , CAS No.823817-56-7
a trizolopyrazine dipeptidyl peptidase IV inhibitor
Basic Description Storage Temp Store at 2-8°C Shipped In Wet ice Product Description Rac-Sitagliptin is a CD26 (trizolopyrazine dipeptidyl peptidase IV, DPP-4) inhibitor. DPP-4 is an enzyme which breaks down incretins such as GLP-1, GIP, and gastrointestinal hormones. rac-Sitagliptin controls the release of insulin by inhibiting these gastrointestinal hormones via inhibiting CD26 (DPP-4). Alternate studies indicate that rac-Sitagliptin can induce hemolysis. Furthermore, rac-Sitagliptin increases the number of insulin-positive β-cells in islets by reducing apoptosis.
Associated Targets(non-human) Names and Identifiers IUPAC Name 3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one INCHI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2 InChi Key MFFMDFFZMYYVKS-UHFFFAOYSA-N Canonical SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N Isomeric SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N PubChem CID 11306691 Molecular Weight 407.31
Chemical and Physical Properties Solubility Soluble in Dichloromethane, Ethyl Acetate and Methanol
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS05 , GHS07 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H318: Causes serious eye damage
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
P319: Get medical help if you feel unwell.
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