Radequinil - 99%, high purity , GABA-A receptor; anion channel inverse agonist, CAS No.219846-31-8, GABA-A receptor; anion channel inverse agonist

Item Number

R647894

Grouped product items
SKU	Size	Availability	Price	Qty
R647894-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90
R647894-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,080.90

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Basic Description

Synonyms	MS-25042 \| SX-3933 \| Q7280124 \| Resequinil [INN] \| 5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine \| AC 3933 \| AKOS040742532 \| AVE-3933 \| JQOFKKWHXGQABB-UHFFFAOYSA-N \| HY-106025 \| DTXSID60944577 \| Radequinil [INN]
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with K i s of 5.15 and 6.11 nM, respectively.
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice
Action Type	INVERSE AGONIST
Mechanism of action	GABA-A receptor; anion channel inverse agonist
Product Description	Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with K i s of 5.15 and 6.11 nM, respectively Form:Solid IC50& Target:Ki: 5.15±0.39 nM (GABA(-) ligand), 6.11±0.26 nM (GABA(+) ligand)

Names and Identifiers

IUPAC Name	5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1H-1,6-naphthyridin-2-one
INCHI	InChI=1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23)
InChi Key	JQOFKKWHXGQABB-UHFFFAOYSA-N
Canonical SMILES	CC1=NC(=NO1)C2=CC3=C(C=CN=C3C4=CC(=CC=C4)OC)NC2=O
Isomeric SMILES	CC1=NC(=NO1)C2=CC3=C(C=CN=C3C4=CC(=CC=C4)OC)NC2=O
Alternate CAS	219846-31-8
PubChem CID	135418404
MeSH Entry Terms	5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine;AC 3933;AC-3933;AC3933
Molecular Weight	334.33

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Basic Description