Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab176088-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
| Ab176088-1mg | 1mg | In stock | $169.90 | |
| Ab176088-5mg | 5mg | In stock | $399.90 | |
| Ab176088-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $659.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ragifilimab (anti-TNFRSF18) - Primary antibody, specific to TNFRSF18, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | Activation inducible TNFR family receptor antibody; Activation-inducible TNFR family receptor antibody; AITR antibody; CD357 antibody; GITR antibody; GITR D antibody; GITR-D antibody; GITRD antibody; Glucocorticoid induced TNFR related protein antibody; g |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | TNFRSF18 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | AGONIST |
| Mechanism of action | AGONIST of Tumor necrosis factor receptor superfamily member 18 agonist |
| Product Description | Ragifilimab (anti-TNFRSF18) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab (anti-TNFRSF18) can be used for advanced or metastatic solid tumors research. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.8 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 176.3 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2207590-51-8 |
Ragifilimab (anti-TNFRSF18) (Ab176088) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling TNFRSF18 with Ragifilimab (anti-TNFRSF18) (Ab176088) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).
Ragifilimab (anti-TNFRSF18) (Ab176088) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling TNFRSF18 (red) with Ragifilimab (anti-TNFRSF18) (Ab176088) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Ragifilimab (anti-TNFRSF18) (Ab176088) - SEC
The purity of Ragifilimab (anti-TNFRSF18) (Ab176088) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1101574 | Certificate of Analysis | Nov 08, 2023 | Ab176088 |
| ZJ23F1101557 | Certificate of Analysis | Nov 08, 2023 | Ab176088 |
| 1. Kwon, B B and 9 more authors.. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.. The Journal of biological chemistry, (5): [PMID:10037686] |
| 2. Gurney, A L AL and 15 more authors.. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.. Current biology : CB, (25): [PMID:10074428] |
| 3. Nocentini, G G and 7 more authors.. (2000) Identification of three novel mRNA splice variants of GITR.. Cell death and differentiation, [PMID:10836847] |
