Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA 2 inhibitor, with an IC 50 of 2.6 μM.
In Vitro
Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC 50 s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively. Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells. Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Associated Targets
MPEG1Tchem Macrophage-expressed gene 1 protein 1 Activities
