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R421377-1ml

1ml

Available within 4-8 weeks(?)

$36.90

Basic Description

Synonyms	rasagiline\|136236-51-6\|(R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine\|Azilect\|(R)-N-2-Propynyl-1-indanamine\|(1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine\|(R)-2,3-dihydro-N-2-propynyl-1H-inden-1-amine\|1-Indanamine, N-2-propynyl-, (R)-\|TV-1030\|Azilect (
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Rasagilan mesylate is an irreversible inhibitor of monoamine oxidase. Its selectivity for Mao of type B is 14 times higher than that of type A. It has anti apoptotic and neuroprotective activities and has been used in the treatment of Parkinson's disease.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Rasagiline mesylate has been used: • to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation • as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model • as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior.

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

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CNR1 Tclin Cannabinoid receptor 1 0 Activities

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DRD1 Tclin D(1A) dopamine receptor 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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ESR1 Tclin Estrogen receptor 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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NR3C1 Tclin Glucocorticoid receptor 0 Activities

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AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

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CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 1 Activities

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 19 Activities

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APP Tclin Amyloid-beta A4 protein 0 Activities

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HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR6 Tchem 5-hydroxytryptamine receptor 6 1 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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BCHE Tclin Cholinesterase 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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OPRD1 Tclin Delta-type opioid receptor 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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MLNR Tchem Motilin receptor 0 Activities

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Names and Identifiers

IUPAC Name	(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
INCHI	InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
InChi Key	RUOKEQAAGRXIBM-GFCCVEGCSA-N
Canonical SMILES	C#CCNC1CCC2=CC=CC=C12
Isomeric SMILES	C#CCN[C@@H]1CCC2=CC=CC=C12
PubChem CID	3052776
Molecular Weight	171.24

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Rasagiline - 10mM in DMSO, high purity , CAS No.136236-51-6