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Recombinant Angiotensin Converting Enzyme 1 Antibody - Primary antibody, specific to ACE, Rabbit IgG

ExactAb™
Recombinant
Validated
0.18 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human Angiotensin Converting Enzyme 1 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse
Isotype: Rabbit IgG

Application:

Item Number

Ab088828

Grouped product items
SKU	Size	Availability	Price	Qty
Ab088828-10μl	10μl	In stock	$66.90

Recombinant; Rabbit anti Human Angiotensin Converting Enzyme 1 Antibody; WB; Unconjugated

View related series

Accession#:P12821 ACE Angiotensin Converting Enzyme 1 Gene ID:1636

Basic Description

Product Name	Recombinant Angiotensin Converting Enzyme 1 Antibody - Primary antibody, specific to ACE, Rabbit IgG
Synonyms	ACE 1 antibody; ACE antibody; ACE T antibody; ACE_HUMAN antibody; ACE1 antibody; Angiotensin converting enzyme somatic isoform antibody; Angiotensin converting enzyme testis specific isoform antibody; Angiotensin I converting enzyme 1 antibody; Angiotensi
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.18 mg/mL
Host species	Rabbit
Specificity	ACE
Immunogen	A synthetic peptide derived from human ACE1 (AA 1250-1306)
Positive Control	WB: Mouse kidney and Mouse lung lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Angiotensin Converting Enzyme 1 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.18 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Angiotensin Converting Enzyme 1 Antibody (Ab088828) - Western Blot
All lanes: Recombinant Angiotensin Converting Enzyme 1 Antibody (Ab088828) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution

Predicted band size: 150 kDa
Observed band size: 181 kDa
Exposure time: 25.9 s

Associated Targets

ACE Tclin Angiotensin-converting enzyme 0 Activities

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/1000

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505870	Certificate of Analysis	May 21, 2024	Ab088828
ZJ24F0505871	Certificate of Analysis	May 21, 2024	Ab088828

FAQs and Articles

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Guidelines of Primary Antibodies for Western Blotting

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References

1. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R et al.. (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.. Circ Res, 87 (5): (E1-9). [PMID:10969042]
2. Michaud A, Williams TA, Chauvet MT, Corvol P. (1997) Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I.. Mol Pharmacol, 51 (6): (1070-6). [PMID:9187274]
3. Lefebvre HP, Brown SA, Chetboul V, King JN, Pouchelon JL, Toutain PL. (2007) Angiotensin-converting enzyme inhibitors in veterinary medicine.. Curr Pharm Des, 13 (13): (1347-61). [PMID:17506720]
4. Robinson DM, Curran MP, Lyseng-Williamson KA. (2007) Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure.. Drugs, 67 (9): (1359-78). [PMID:17547476]
5. Ceconi C, Francolini G, Olivares A, Comini L, Bachetti T, Ferrari R. (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE.. Eur J Pharmacol, 577 (1-3): (1-6). [PMID:17716647]
6. Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, Bouton JM, Feuillet F, Makni S, Ben Amar H et al.. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.. Nat Genet, 37 (9): (964-8). [PMID:16116425]
7. Eyries M, Michaud A, Deinum J, Agrapart M, Chomilier J, Kramers C, Soubrier F. (2001) Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.. J Biol Chem, 276 (8): (5525-32). [PMID:11076943]
8. Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.. Bioorg Med Chem Lett, 18 (2): (732-7). [PMID:18078750]
9. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.. Bioorg Med Chem, 16 (19): (8781-94). [PMID:18790648]
10. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.. J Med Chem, 52 (18): (5732-47). [PMID:19715320]
11. Gomez-Monterrey I, Beaumont A, Nemecek P, Roques BP, Fournie-Zaluski MC.. (1994) New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.. J Med Chem, 37 (12): (1865-1873). [PMID:8021926]
12. Berger Y, Dehmlow H, Blum-Kaelin D, Kitas EA, Löffler BM, Aebi JD, Juillerat-Jeanneret L.. (2005) Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.. J Med Chem, 48 (2): (483-498). [PMID:15658862]
13. Deaton DN, Graham KP, Gross JW, Miller AB.. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.. Bioorg Med Chem Lett, 18 (5): (1681-1687). [PMID:18243695]
14. Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP.. (2008) Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.. J Med Chem, 51 (14): (4150-4169). [PMID:18588282]
15. Madsen JL, Andersen TL, Santamaria S, Nagase H, Enghild JJ, Skrydstrup T.. (2012) Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.. J Med Chem, 55 (17): (7900-7908). [PMID:22882079]
16. Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA.. (2013) Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.. J Med Chem, 56 (6): (2246-2255). [PMID:23437776]
17. Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H.. (2013) Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.. J Med Chem, 56 (3): (1276-1290). [PMID:23350733]
18. Day JA, Cohen SM.. (2013) Investigating the selectivity of metalloenzyme inhibitors.. J Med Chem, 56 (20): (7997-8007). [PMID:24074025]
19. Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R.. (2014) Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.. Eur J Med Chem, 79 (184-193). [PMID:24735644]
20. Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D.. (2014) Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.. J Med Chem, 57 (22): (9598-9611). [PMID:25330343]
21. Huard K, Gosset JR, Montgomery JI, Gilbert A, Hayward MM, Magee TV, Cabral S, Uccello DP, Bahnck K, Brown J, Purkal J, Gorgoglione M, Lanba A, Futatsugi K, Herr M, Genung NE, Aspnes G, Polivkova J, Garcia-Irizarry CN, Li Q, Canterbury D, Niosi M, Vera NB, Li Z, Khunte B, Siderewicz J, Rolph T, Erion DM.. (2016) Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.. J Med Chem, 59 (3): (1165-1175). [PMID:26734723]
22. Choi JY, Fuerst R, Knapinska AM, Taylor AB, Smith L, Cao X, Hart PJ, Fields GB, Roush WR.. (2017) Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.. J Med Chem, 60 (13): (5816-5825). [PMID:28653849]
23. Sattigeri JA, Sethi S, Davis JA, Ahmed S, Rayasam GV, Jadhav BG, Chilla SM, Datta D, Gadhave A, Tulasi VK, Jain T, Voleti S, Benjamin B, Udupa S, Jain G, Singh Y, Srinivas K, Bansal VS, Ray A, Bhatnagar PK, Cliffe IA.. (2017) Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.. Bioorg Med Chem Lett, 27 (11): (2313-2318). [PMID:28442252]
24. Ke Z, Su Z, Zhang X, Cao Z, Ding Y, Cao L, Ding G, Wang Z, Liu H, Xiao W.. (2017) Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening.. Bioorg Med Chem Lett, 27 (16): (3688-3692). [PMID:28712707]
25. Manikandan A, Moharil P, Sathishkumar M, Muñoz-Garay C, Sivakumar A.. (2017) Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.. Eur J Med Chem, 141 (417-426). [PMID:29032034]
26. McKinnell RM, Fatheree P, Choi SK, Gendron R, Jendza K, Olson Blair B, Budman J, Hill CM, Hegde LG, Yu C, McConn D, Hegde SS, Marquess DG, Klein U.. (2019) Discovery of TD-0212, an Orally Active Dual Pharmacology AT₁ Antagonist and Neprilysin Inhibitor (ARNI).. ACS Med Chem Lett, 10 (1): (86-91). [PMID:30655952]
27. Sharma U, Cozier GE, Sturrock ED, Acharya KR.. (2020) Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.. J Med Chem, 63 (10): (5488-5500). [PMID:32337993]
28. Dow RL,Ammirati M,Bagley SW,Bhattacharya SK,Buckbinder L,Cortes C,El-Kattan AF,Ford K,Freeman GB,Guimarães CRW,Liu S,Niosi M,Skoura A,Tess D. (2018) 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.. J Med Chem, 61 (7): (3114-3125). [PMID:29570292]
29. Wei, L L, Clauser, E E, Alhenc-Gelas, F F and Corvol, P P.. (1992) The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.. The Journal of biological chemistry, (5): [PMID:1320019]
30. Rosendorff, C C, Patton, J J, Radford, H M HM and Kalliatakis, B B.. (1992) Alpha-adrenergic and angiotensin II pressor sensitivity in hypertensive patients treated with an angiotensin-converting enzyme inhibitor.. Journal of cardiovascular pharmacology, [PMID:1382157]
31. Ehlers, M R MR and Riordan, J F JF.. (1991) Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes.. Biochemistry, (23): [PMID:1649623]
32. Ehlers, M R MR, Chen, Y N YN and Riordan, J F JF.. (1991) Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells.. Protein expression and purification, [PMID:1668266]
33. Wei, L L, Alhenc-Gelas, F F, Corvol, P P and Clauser, E E.. (1991) The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.. The Journal of biological chemistry, (15): [PMID:1851160]
34. Lattion, A L AL and 5 more authors.. (1989) The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme.. FEBS letters, (31): [PMID:2547653]
35. Ehlers, M R MR, Fox, E A EA, Strydom, D J DJ and Riordan, J F JF.. (1989) Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2554286]
36. Takeuchi, K K and 5 more authors.. (1989) Purification of human lung angiotensin-converting enzyme by high-performance liquid chromatography: properties and N-terminal amino acid sequence.. Journal of biochemistry, [PMID:2558109]
37. Soubrier, F F and 6 more authors.. (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2849100]
38. Skidgel, R A RA and Erdös, E G EG.. (1985) Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2983326]
39. Yang, H Y HY, Erdös, E G EG and Levin, Y Y.. (1970) A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.. Biochimica et biophysica acta, (21): [PMID:4322742]
40. Skidgel, R A RA, Engelbrecht, S S, Johnson, A R AR and Erdös, E G EG.. () Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase.. Peptides, [PMID:6208535]
41. Jaspard, E E, Wei, L L and Alhenc-Gelas, F F.. (1993) Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides.. The Journal of biological chemistry, (5): [PMID:7683654]
42. Rousseau, A A, Michaud, A A, Chauvet, M T MT, Lenfant, M M and Corvol, P P.. (1995) The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme.. The Journal of biological chemistry, (24): [PMID:7876104]
43. Beldent, V V, Michaud, A A, Wei, L L, Chauvet, M T MT and Corvol, P P.. (1993) Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site.. The Journal of biological chemistry, (15): [PMID:8253769]
44. Sturrock, E D ED, Yu, X C XC, Wu, Z Z, Biemann, K K and Riordan, J F JF.. (1996) Assignment of free and disulfide-bonded cysteine residues in testis angiotensin-converting enzyme: functional implications.. Biochemistry, (23): [PMID:8755737]
45. Yu, X C XC and 5 more authors.. (1997) Identification of N-linked glycosylation sites in human testis angiotensin-converting enzyme and expression of an active deglycosylated form.. The Journal of biological chemistry, (7): [PMID:9013598]
46. Vleming, L J LJ and 7 more authors.. (1999) The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.. Clinical nephrology, [PMID:10099885]
47. Yoshiyama, M M and 9 more authors.. (1999) Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography.. Hypertension (Dallas, Tex. : 1979), [PMID:10205231]
48. Rieder, M J MJ, Taylor, S L SL, Clark, A G AG and Nickerson, D A DA.. (1999) Sequence variation in the human angiotensin converting enzyme.. Nature genetics, [PMID:10319862]
49. Halushka, M K MK and 8 more authors.. (1999) Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.. Nature genetics, [PMID:10391210]
50. Kihara, M M and 6 more authors.. (1999) Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: role of nitric oxide.. Muscle & nerve, [PMID:10398211]
51. Mervaala, E E and 7 more authors.. (1999) Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes.. Journal of the American Society of Nephrology : JASN, [PMID:10446934]
52. Woodman, Z L ZL and 7 more authors.. (2000) Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.. The Biochemical journal, (1): [PMID:10769174]
53. Araujo, M C and 5 more authors.. (2000) Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.. Biochemistry, (25): [PMID:10913258]
54. Tipnis, S R SR and 5 more authors.. (2000) A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.. The Journal of biological chemistry, (27): [PMID:10924499]
55. and Piepho, R W RW.. (2000) Overview of the angiotensin-converting-enzyme inhibitors.. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, (1): [PMID:11030016]
56. Sharma, S S and 5 more authors.. (1999) The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group.. American journal of therapeutics, [PMID:11329095]
57. Kramers, C C and 11 more authors.. (2001) Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease.. Circulation, (11): [PMID:11551873]
58. and Ferdinand, K C KC.. () Advances in antihypertensive combination therapy: benefits of low-dose thiazide diuretics in conjunction with omapatrilat, a vasopeptidase inhibitor.. Journal of clinical hypertension (Greenwich, Conn.), [PMID:11588409]
59. Hu, J J, Igarashi, A A, Kamata, M M and Nakagawa, H H.. (2001) Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.. The Journal of biological chemistry, (21): [PMID:11604391]
60. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]
61. Culy, Christine R CR and Jarvis, Blair B.. (2002) Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders.. Drugs, [PMID:11817979]
62. Song, Jessica C JC and White, C Michael CM.. (2002) Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update.. Clinical pharmacokinetics, [PMID:11929321]
63. Kohlstedt, Karin K, Shoghi, Firouzeh F, Müller-Esterl, Werner W, Busse, Rudi R and Fleming, Ingrid I.. (2002) CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane.. Circulation research, (18): [PMID:12386153]
64. Harmer, Dan D, Gilbert, Maureen M, Borman, Richard R and Clark, Kenneth L KL.. (2002) Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.. FEBS letters, (4): [PMID:12459472]
65. Natesh, Ramanathan R, Schwager, Sylva L U SL, Sturrock, Edward D ED and Acharya, K Ravi KR.. (2003) Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.. Nature, (30): [PMID:12540854]
66. Gordon, Kerry K and 7 more authors.. (2003) Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.. The Biochemical journal, (15): [PMID:12542396]
67. Neal, Bruce B and 5 more authors.. (2002) Effects of the vasopeptidase inhibitor, omapatrilat, in 723 patients with coronary heart disease.. Journal of the renin-angiotensin-aldosterone system : JRAAS, [PMID:12584671]
68. Arend, U U, Albrecht, S S, Meisel, E E and Schmidt, J J.. (2002) [Influence of ACE inhibitor spirapril on left ventricular hypertrophy].. Fortschritte der Medizin. Originalien, (5): [PMID:12613273]
69. Linnebank, M M and 6 more authors.. (2003) Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis.. Neurology, (23): [PMID:14694062]
70. Goulter, Andrew B AB, Goddard, Martin J MJ, Allen, Jennifer C JC and Clark, Kenneth L KL.. (2004) ACE2 gene expression is up-regulated in the human failing heart.. BMC medicine, (19): [PMID:15151696]
71. Natesh, Ramanathan R, Schwager, Sylva L U SL, Evans, Hazel R HR, Sturrock, Edward D ED and Acharya, K Ravi KR.. (2004) Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.. Biochemistry, (13): [PMID:15236580]
72. Slowik, A A and 9 more authors.. (2004) DD genotype of ACE gene is a risk factor for intracerebral hemorrhage.. Neurology, (27): [PMID:15277638]
73. Chrysant, Steven G SG and Chrysant, George S GS.. (2004) Pharmacological and clinical profile of moexipril: a concise review.. Journal of clinical pharmacology, [PMID:15286086]
74. Casas, Juan P JP, Hingorani, Aroon D AD, Bautista, Leonelo E LE and Sharma, Pankaj P.. (2004) Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.. Archives of neurology, [PMID:15534175]
75. Naqvi, Nawazish N, Liu, Ke K, Graham, Robert M RM and Husain, Ahsan A.. (2005) Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: insights into the origins of its exopeptidase activity.. The Journal of biological chemistry, (25): [PMID:15615692]
76. Burrell, Louise M LM and 11 more authors.. (2005) Myocardial infarction increases ACE2 expression in rat and humans.. European heart journal, [PMID:15671045]
77. Maul, Björn B and 8 more authors.. (2005) Central angiotensin II controls alcohol consumption via its AT1 receptor.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:16126915]
78. Hemming, Matthew L ML and Selkoe, Dennis J DJ.. (2005) Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.. The Journal of biological chemistry, (11): [PMID:16154999]
79. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
80. Levitt, David G and Schoemaker, Rik C.. (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.. BMC clinical pharmacology, (6): [PMID:16398929]
81. Liu, Yu-Hui YH, Liu, Li-Ying LY, Wu, Jin-Xiang JX, Chen, Shuang-Xiu SX and Sun, Yin-Xue YX.. (2006) Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice.. Journal of cardiovascular pharmacology, [PMID:16424790]
82. Corradi, Hazel R HR, Schwager, Sylva L U SL, Nchinda, Aloysius T AT, Sturrock, Edward D ED and Acharya, K Ravi KR.. (2006) Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.. Journal of molecular biology, (31): [PMID:16476442]
83. Zody, Michael C MC and 73 more authors.. (2006) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.. Nature, (20): [PMID:16625196]
84. and Ambrosioni, Ettore E.. (2007) Defining the role of zofenopril in the management of hypertension and ischemic heart disorders.. American journal of cardiovascular drugs : drugs, devices, and other interventions, [PMID:17355163]
85. Tylicki, Leszek L and 6 more authors.. (2008) Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial.. American journal of kidney diseases : the official journal of the National Kidney Foundation, [PMID:18423812]
86. Brugts, Jasper J JJ, Ferrari, Roberto R and Simoons, Maarten L ML.. (2009) Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease.. Expert review of cardiovascular therapy, [PMID:19379059]
87. Zou, Kun K and 8 more authors.. (2009) Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme.. The Journal of biological chemistry, (13): [PMID:19773553]
88. Hermida, Ramón C RC and 5 more authors.. (2010) Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension.. Chronobiology international, [PMID:20524801]
89. Anthony, Colin S CS and 7 more authors.. (2010) The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.. The Journal of biological chemistry, (12): [PMID:20826823]
90. Akif, Mohd M and 7 more authors.. (2011) Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.. The FEBS journal, [PMID:21810173]
91. Barauna, Valerio Garrone VG, Campos, Luciene Cristina Gastalho LC, Miyakawa, Ayumi Aurea AA and Krieger, Jose Eduardo JE.. (2011) ACE as a mechanosensor to shear stress influences the control of its own regulation via phosphorylation of cytoplasmic Ser(1270).. PloS one, [PMID:21901117]
92. Masuyer, Geoffrey; Schwager, Sylva L U; Sturrock, Edward D; Isaac, R Elwyn and Acharya, K Ravi.. (2012) Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.. Scientific reports, [PMID:23056909]
93. Yates, Christopher J CJ and 5 more authors.. (2014) Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE).. The Journal of biological chemistry, (17): [PMID:24297181]
94. Cromer, M Kyle MK and 16 more authors.. (2015) Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:25787250]
95. Masuyer, Geoffrey G, Douglas, Ross G RG, Sturrock, Edward D ED and Acharya, K Ravi KR.. (2015) Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme.. Scientific reports, (25): [PMID:26403559]

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