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BCRP/ABCG2 Mouse mAb - Primary antibody, specific to ABCG2, IgG1

ExactAb™
Recombinant
Validated
Lot by Lot

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human BCRP/ABCG2 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Rabbit IgG

Application:

Item Number

Ab090883

Grouped product items
SKU	Size	Availability	Price
Ab090883-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
Ab090883-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$219.90
Ab090883-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$349.90
Ab090883-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,399.90

Recombinant; Rabbit anti Human BCRP/ABCG2 Antibody; WB; Unconjugated

View related series

ABCG2 Accession#:Q9UNQ0 BCRP Gene ID:9429

Basic Description

Product Name	BCRP/ABCG2 Mouse mAb - Primary antibody, specific to ABCG2, IgG1
Synonyms	ABC transporter antibody; ABC15 antibody; ABCG 2 antibody; ABCG2 antibody; ABCG2_HUMAN antibody; ABCP antibody; ATP binding cassette sub family G (WHITE) member 2 antibody; ATP binding cassette transporter G2 antibody; ATP-binding cassette sub-family G me
Specifications & Purity	ExactAb™, Validated, Recombinant, Lot by Lot
Host species	Rabbit
Specificity	ABCG2
Immunogen	A synthetic peptide derived from human BCRP/ABCG2 (AA 150-200).
Positive Control	WB: HEK293, HeLa, Jurkat, Hep G2 and MCF7 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human BCRP/ABCG2 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant BCRP/ABCG2 Antibody (Ab090883) - Western Blot
All lanes: Recombinant BCRP/ABCG2 Antibody (Ab090883) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 72 kDa
Observed band size: 75 kDa
Exposure time: 30.0 s

Associated Targets

ABCG2 Tchem ATP-binding cassette sub-family G member 2 0 Activities

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/2000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0708380	Certificate of Analysis	Jul 17, 2024	Ab090883
ZJ24F0708379	Certificate of Analysis	Jul 17, 2024	Ab090883

References

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21. Gedeon C, Behravan J, Koren G, Piquette-Miller M.. (2006) Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.. Placenta, 27 (1): (1096-1102). [PMID:16460798]
22. Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, Nooter K.. (2004) Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.. Blood, 104 (1): (2940-2942). [PMID:15251980]
23. Komatani H, Kotani H, Hara Y, Nakagawa R, Matsumoto M, Arakawa H, Nishimura S.. (2001) Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.. Cancer Res, 61 (1): (2827-2832). [PMID:11306452]
24. Minderman H, O'Loughlin KL, Pendyala L, Baer MR.. (2004) VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.. Clin Cancer Res, 10 (1): (1826-1834). [PMID:15014037]
25. Mitomo H, Kato R, Ito A, Kasamatsu S, Ikegami Y, Kii I, Kudo A, Kobatake E, Sumino Y, Ishikawa T.. (2003) A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.. Biochem J, 373 (1): (767-774). [PMID:12741957]
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28. Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y.. (2003) ABCG2 transports sulfated conjugates of steroids and xenobiotics.. J Biol Chem, 278 (1): (22644-22649). [PMID:12682043]
29. Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, Oka M, Kohno S, Sawada S, Ishikawa T, Tanabe S.. (2004) Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.. Int J Cancer, 110 (1): (921-927). [PMID:15170677]
30. Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P.. (2004) Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.. Cancer Res, 64 (1): (2333-2337). [PMID:15059881]
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32. Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.. (2014) Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.. J Med Chem, 57 (20): (8503-8516). [PMID:25310383]
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34. Yang Z, Zhu W, Gao S, Yin T, Jiang W, Hu M.. (2012) Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein.. Drug Metab Dispos, 40 (10): (1883-1893). [PMID:22736306]
35. Wittgen HG, van den Heuvel JJ, van den Broek PH, Siissalo S, Groothuis GM, de Graaf IA, Koenderink JB, Russel FG.. (2012) Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4.. Drug Metab Dispos, 40 (6): (1076-1079). [PMID:22415933]
36. Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG.. (2013) Characterization of efflux transporters involved in distribution and disposition of apixaban.. Drug Metab Dispos, 41 (4): (827-835). [PMID:23382458]
37. Poller B, Iusuf D, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.. (2011) Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.. Drug Metab Dispos, 39 (5): (729-735). [PMID:21282407]
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42. Krapf MK, Gallus J, Wiese M.. (2017) Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).. Eur J Med Chem, 139 (587-611). [PMID:28841513]
43. Buchler I, Akuma D, Au V, Carr G, de León P, DePasquale M, Ernst G, Huang Y, Kimos M, Kolobova A, Poslusney M, Wei H, Swinnen D, Montel F, Moureau F, Jigorel E, Schulze MED, Wood M, Barrow JC.. (2018) Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.. J Med Chem, 61 (21): (9647-9665). [PMID:30272964]
44. Wong ILK, Zhu X, Chan KF, Law MC, Lo AMY, Hu X, Chow LMC, Chan TH.. (2018) Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".. J Med Chem, 61 (22): (9931-9951). [PMID:30351934]
45. Zhu X, Wong ILK, Chan KF, Cui J, Law MC, Chong TC, Hu X, Chow LMC, Chan TH.. (2019) Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.. J Med Chem, 62 (18): (8578-8608). [PMID:31465686]
46. Chatzopoulou M, Claridge TDW, Davies KE, Davies SG, Elsey DJ, Emer E, Fletcher AM, Harriman S, Robinson N, Rowley JA, Russell AJ, Tinsley JM, Weaver R, Wilkinson IVL, Willis NJ, Wilson FX, Wynne GM.. (2020) Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.. J Med Chem, 63 (5): (2547-2556). [PMID:31599580]
47. Silbermann K, Shah CP, Sahu NU, Juvale K, Stefan SM, Kharkar PS, Wiese M.. (2019) Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.. Eur J Med Chem, 164 (193-213). [PMID:30594677]
48. Wu CP, Lusvarghi S, Hsiao SH, Liu TC, Li YQ, Huang YH, Hung TH, Ambudkar SV.. (2020) Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.. J Nat Prod, 83 (5): (1461-1472). [PMID:32347726]
49. Silbermann K,Li J,Namasivayam V,Stefan SM,Wiese M. (2021) Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.. Eur J Med Chem, 212 (113045-113045). [PMID:33454462]
50. Guragossian N, Belhani B, Moreno A, Nunes MT, Gonzalez-Lobato L, Marminon C, Berthier L, Rocio Andrade Pires AD, Özvegy-Laczka C, Sarkadi B, Terreux R, Bouaziz Z, Berredjem M, Jose J, Di Pietro A, Falson P, Le Borgne M.. (2021) Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.. Eur J Med Chem, 211 (113017-113017). [PMID:33223263]
51. Kumar S, Jaipuri FA, Waldo JP, Potturi H, Marcinowicz A, Adams J, Van Allen C, Zhuang H, Vahanian N, Link C, Brincks EL, Mautino MR.. (2020) Discovery of indoximod prodrugs and characterization of clinical candidate NLG802.. Eur J Med Chem, 198 (112373-112373). [PMID:32422549]
52. Zhou, S S and 10 more authors.. (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.. Nature medicine, [PMID:11533706]
53. Iida, Aritoshi A and 8 more authors.. (2002) Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.. Journal of human genetics, [PMID:12111378]
54. Zhang, Wandong W and 5 more authors.. (2003) The expression and functional characterization of ABCG2 in brain endothelial cells and vessels.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:12958161]
55. Xu, Junkang J, Liu, Yang Y, Yang, Youyun Y, Bates, Susan S and Zhang, Jian-Ting JT.. (2004) Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2.. The Journal of biological chemistry, (7): [PMID:15001581]
56. Itoda, Masaya M and 10 more authors.. (2003) Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.. Drug metabolism and pharmacokinetics, [PMID:15618737]
57. Ozvegy-Laczka, Csilla C, Köblös, Gabriella G, Sarkadi, Balázs B and Váradi, András A.. (2005) Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition.. Biochimica et biophysica acta, (1): [PMID:15670731]
58. Henriksen, Ulla U, Gether, Ulrik U and Litman, Thomas T.. (2005) Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.. Journal of cell science, (1): [PMID:15769853]
59. Diop, Ndeye K NK and Hrycyna, Christine A CA.. (2005) N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.. Biochemistry, (12): [PMID:15807535]
60. Hillier, Ladeana W LW and 121 more authors.. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature, (7): [PMID:15815621]
61. Morisaki, Kuniaki K and 7 more authors.. (2005) Single nucleotide polymorphisms modify the transporter activity of ABCG2.. Cancer chemotherapy and pharmacology, [PMID:15838659]
62. Wakabayashi, Kanako K and 6 more authors.. (2007) Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein.. The Journal of biological chemistry, (21): [PMID:17686774]
63. Xie, Yingqiu Y and 11 more authors.. (2008) The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.. The Journal of biological chemistry, (8): [PMID:18056989]
64. Dehghan, Abbas A and 14 more authors.. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.. Lancet (London, England), (6): [PMID:18834626]
65. Woodward, Owen M OM and 5 more authors.. (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.. Proceedings of the National Academy of Sciences of the United States of America, (23): [PMID:19506252]
66. Henrich, Curtis J and 8 more authors.. (2009) Botryllamides: natural product inhibitors of ABCG2.. ACS chemical biology, (21): [PMID:19555120]
67. Takabe, Kazuaki K and 9 more authors.. (2010) Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.. The Journal of biological chemistry, (2): [PMID:20110355]
68. Brechbuhl, Heather M HM and 5 more authors.. (2010) Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2.. The Journal of biological chemistry, (28): [PMID:20332504]
69. Matsuo, Hirotaka H and 33 more authors.. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.. Science translational medicine, (4): [PMID:20368174]
70. Desuzinges-Mandon, Elodie E and 5 more authors.. (2010) ABCG2 transports and transfers heme to albumin through its large extracellular loop.. The Journal of biological chemistry, (22): [PMID:20705604]
71. Nakayama, Akiyoshi A and 10 more authors.. (2011) ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans.. Nucleosides, nucleotides & nucleic acids, [PMID:22132962]
72. Saison, Carole C and 11 more authors.. (2012) Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior.. Nature genetics, (15): [PMID:22246505]
73. Zelinski, Teresa T, Coghlan, Gail G, Liu, Xiao-Qing XQ and Reid, Marion E ME.. (2012) ABCG2 null alleles define the Jr(a-) blood group phenotype.. Nature genetics, (15): [PMID:22246507]
74. Manolaridis, Ioannis I and 5 more authors.. (2018) Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.. Nature, [PMID:30405239]
75. Toyoda, Yu Y and 11 more authors.. (2019) Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort.. Cells, (18): [PMID:31003562]
76. Zámbó, Boglárka B and 8 more authors.. (2019) Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter.. Cellular and molecular life sciences : CMLS, (28): [PMID:31254042]

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