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Recombinant BRCA1 Antibody - Primary antibody, specific to BRCA1, Mouse IgG1

ExactAb™
Recombinant
Validated
4.8 mg/mL

Features and benefits

Short Overview:
Recombinant (MyM1-BRCA-1); Mouse anti Human BRCA1 Antibody; IHC; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Mouse IgG1

Application:

Item Number

Ab091629

Grouped product items
SKU	Size	Availability	Price
Ab091629-10μl	10μl	In stock	$69.90
Ab091629-50μl	50μl	In stock	$199.90
Ab091629-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$309.90
Ab091629-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,499.90

Recombinant (MyM1-BRCA-1); Mouse anti Human BRCA1 Antibody; IHC; Unconjugated

View related series

Accession#:P38398 BRCA1 Gene ID:672

Basic Description

Product Name	Recombinant BRCA1 Antibody - Primary antibody, specific to BRCA1, Mouse IgG1
Specifications & Purity	ExactAb™, Validated, Recombinant, 4.8 mg/mL
Host species	Mouse
Specificity	BRCA1
Positive Control	IHC: Human breast tissue.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Mouse anti Human BRCA1 Antibody, Recombinant (MyM1-BRCA-1), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.

Product Properties

Isotype	Mouse IgG1
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	4.8 mg/mL
Storage Temp	Store at 2-8°C,Avoid repeated freezing and thawing
Shipped In	Wet ice
Stability And Storage	Store at 2-8°C long term (36 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant BRCA1 Antibody (Ab091629) - IHC
Immunohistochemistry analysis of paraffin-embedded human breast tissue labelling BRCA1 with Recombinant BRCA1 Antibody (Ab091629) at 1/100 dilution. The section was incubated with Ab091629 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.

Application

Dilution info

IHC

1/100 - 1/200

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505164	Certificate of Analysis	May 07, 2024	Ab091629
ZJ24F0505163	Certificate of Analysis	May 07, 2024	Ab091629

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