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Recombinant Claudin 1 Antibody - Primary antibody, specific to Claudin 1, Rabbit IgG

  • ExactAb™
  • Recombinant
  • Validated
  • 1.5 mg/mL
Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human Claudin 1 Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab096695
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab096695-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab096695-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
Ab096695-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab096695-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,499.90

Recombinant; Rabbit anti Human Claudin 1 Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant Claudin 1 Antibody - Primary antibody, specific to Claudin 1, Rabbit IgG
SynonymsClaudin-1 antibody|Claudin1 antibody|CLD 1 antibody|CLD1 antibody|CLD1_HUMAN antibody|CLDN 1 antibody|Cldn1 antibody|ILVASC antibody|SEMP 1 antibody|SEMP1 antibody|Senescence associated epithelial membrane protein 1 antibody|Senescence associated epitheli
Specifications & PurityExactAb™, Validated, Recombinant, 1.5 mg/mL
Host speciesRabbit
SpecificityClaudin 1
ImmunogenA synthetic peptide derived from human Claudin 1 (AA 180-211)
Positive ControlWB: A431 and Hep G2 cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Claudin 1 Antibody, Recombinant, could be used for WB and so on.
Application
WB: 1/500-1/2000
Protein Function
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration1.5 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Claudin 1 Antibody (Ab096695) - Western Blot
All lanes: Recombinant Claudin 1 Antibody (Ab096695) at 1/2000 dilution
Samples: Lysates at 10 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 23 kDa
Observed band size: 20 kDa
Exposure time: 6.9 s

Associated Targets

CLDN1 Tbio Claudin-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/2000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0606673Certificate of AnalysisJun 11, 2024 Ab096695
ZJ24F0606674Certificate of AnalysisJun 11, 2024 Ab096695

Related Documents

References

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al..  (2003)  The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment..  Genome Res,  13  (10): (2265-70).  [PMID:12975309]
2. Swisshelm, K K and 5 more authors..  (1999)  SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily..  Gene,    (21):   [PMID:9931503]
3. Halford, S S and 5 more authors..  (2000)  Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids..  Cytogenetics and cell genetics,      [PMID:10828592]
4. Krämer, F F, White, K K, Kubbies, M M, Swisshelm, K K and Weber, B H BH..  (2000)  Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer..  Human genetics,      [PMID:11071387]
5. Hadj-Rabia, Smail S and 10 more authors..  (2004)  Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease..  Gastroenterology,      [PMID:15521008]
6. Feldmeyer, L L and 5 more authors..  (2006)  Confirmation of the origin of NISCH syndrome..  Human mutation,      [PMID:16619213]
7. Evans, Matthew J MJ and 9 more authors..  (2007)  Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry..  Nature,    (12):   [PMID:17325668]
8. Harris, Helen J HJ and 11 more authors..  (2010)  Claudin association with CD81 defines hepatitis C virus entry..  The Journal of biological chemistry,    (2):   [PMID:20375010]
9. Lupberger, Joachim J and 25 more authors..  (2011)  EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy..  Nature medicine,      [PMID:21516087]
10. Kirschner, Nina N and 5 more authors..  (2013)  Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes..  The Journal of investigative dermatology,      [PMID:23407391]
11. Bonander, Nicklas and 13 more authors..  (2013)  Production, purification and characterization of recombinant, full-length human claudin-1..  PloS one,      [PMID:23704991]
12. Che, Pulin P, Tang, Hengli H and Li, Qianjun Q..  (2013)  The interaction between claudin-1 and dengue viral prM/M protein for its entry..  Virology,      [PMID:24074594]

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