Recombinant; Rabbit anti Human DAP12 Antibody; WB; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab099136-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
| Ab099136-50μl | 50μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
| Ab099136-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab099136-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,499.90 |
Recombinant; Rabbit anti Human DAP12 Antibody; WB; Unconjugated
| Product Name | Recombinant DAP12 Antibody - Primary antibody, specific to DAP12, Rabbit IgG |
|---|---|
| Synonyms | DAP 12 antibody | DAP12 antibody | DNAX activation protein 12 antibody | DNAX-activation protein 12 antibody | KAR-associated protein antibody | KARAP antibody | Killer activating receptor associated protein antibody | Killer-activating receptor-associate |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 1.1 mg/mL |
| Host species | Rabbit |
| Specificity | DAP12 |
| Immunogen | A synthetic peptide derived from human DAP12 (AA 60-113) |
| Positive Control | WB: THP-1 cell lysate. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description |
Rabbit anti Human DAP12 Antibody, Recombinant, could be used for WB and so on. |
| Isotype | Rabbit IgG |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant DAP12 Antibody (Ab099136) - Western Blot
All lanes: Recombinant DAP12 Antibody (Ab099136) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 12 kDa
Observed band size: 14 kDa
Exposure time: 10.0 s
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0708997 | Certificate of Analysis | Jul 31, 2024 | Ab099136 |
| ZJ24F0708998 | Certificate of Analysis | Jul 31, 2024 | Ab099136 |
| 1. Lanier, L L LL, Corliss, B C BC, Wu, J J, Leong, C C and Phillips, J H JH.. (1998) Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.. Nature, (12): [PMID:9490415] |
| 2. Lanier, L L LL, Corliss, B B, Wu, J J and Phillips, J H JH.. (1998) Association of DAP12 with activating CD94/NKG2C NK cell receptors.. Immunity, [PMID:9655483] |
| 3. Bakker, A B AB, Baker, E E, Sutherland, G R GR, Phillips, J H JH and Lanier, L L LL.. (1999) Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.. Proceedings of the National Academy of Sciences of the United States of America, (17): [PMID:10449773] |
| 4. Dietrich, J J, Cella, M M, Seiffert, M M, Bühring, H J HJ and Colonna, M M.. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:10604985] |
| 5. Bouchon, A A, Dietrich, J J and Colonna, M M.. (2000) Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10799849] |
| 6. Paloneva, J J and 12 more authors.. (2000) Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.. Nature genetics, [PMID:10888890] |
| 7. Bouchon, A A, Hernández-Munain, C C, Cella, M M and Colonna, M M.. (2001) A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.. The Journal of experimental medicine, (15): [PMID:11602640] |
| 8. Gingras, Marie-Claude MC, Lapillonne, Hélène H and Margolin, Judith F JF.. (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.. Molecular immunology, [PMID:11922939] |
| 9. Kondo, T T and 10 more authors.. (2002) Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms.. Neurology, (8): [PMID:12370476] |
| 10. Grimwood, Jane J and 97 more authors.. (2004) The DNA sequence and biology of human chromosome 19.. Nature, (1): [PMID:15057824] |
| 11. Aguilar, Helena H and 5 more authors.. (2004) Molecular characterization of a novel immune receptor restricted to the monocytic lineage.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:15557162] |
| 12. Gumá, Mónica M and 6 more authors.. (2005) The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.. European journal of immunology, [PMID:15940674] |
| 13. Kimura, Kouichi K and 31 more authors.. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome research, [PMID:16344560] |
| 14. Martínez-Barriocanal, Agueda A and Sayós, Joan J.. (2006) Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:16920917] |
| 15. Angata, Takashi T, Hayakawa, Toshiyuki T, Yamanaka, Masahiro M, Varki, Ajit A and Nakamura, Mitsuru M.. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:17012248] |
| 16. Yamanishi, Yoshinori Y and 13 more authors.. (2008) Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.. Blood, (15): [PMID:17928527] |
| 17. Della Chiesa, Mariella M and 8 more authors.. (2008) Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.. European journal of immunology, [PMID:18624290] |
| 18. Helming, Laura L and 6 more authors.. (2008) Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.. Science signaling, (28): [PMID:18957693] |
| 19. Call, Matthew E ME, Wucherpfennig, Kai W KW and Chou, James J JJ.. (2010) The structural basis for intramembrane assembly of an activating immunoreceptor complex.. Nature immunology, [PMID:20890284] |
| 20. Nakano-Yokomizo, Takako T and 16 more authors.. (2011) The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.. The Journal of experimental medicine, (1): [PMID:21727189] |
| 21. Mulrooney, Tiernan J TJ, Posch, Phillip E PE and Hurley, Carolyn Katovich CK.. (2013) DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells.. Journal of leukocyte biology, [PMID:23715743] |
| 22. Zhong, Li L and 8 more authors.. (2015) DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.. The Journal of biological chemistry, (19): [PMID:25957402] |
| 23. Knoblich, Konstantin and 10 more authors.. (2015) Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.. Cell reports, (26): [PMID:25981043] |
| 24. Niizuma, Kouta K, Tahara-Hanaoka, Satoko S, Noguchi, Emiko E and Shibuya, Akira A.. (2015) Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.. The Journal of biological chemistry, (4): [PMID:26221034] |
| 25. Pottier, Cyril C and 29 more authors.. (2016) TYROBP genetic variants in early-onset Alzheimer's disease.. Neurobiology of aging, [PMID:27658901] |
| 26. Darwent, Lee L and 13 more authors.. (2017) Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.. Neurobiology of aging, [PMID:28716534] |
