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Recombinant Glukagon Antibody - Primary antibody, specific to Human, IgG

ExactAb™
Recombinant
Validated
0.3 mg/mL

Features and benefits

Short Overview:
Recombinant (EP3070); Rabbit anti Human Glucagon Antibody; IHC; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: IgG

Application:

Item Number

Ab105544

Grouped product items
SKU	Size	Availability	Price
Ab105544-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90
Ab105544-50μl	50μl	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$198.90
Ab105544-100μl	100μl	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$297.90
Ab105544-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,107.90

Recombinant (EP3070); Rabbit anti Human Glucagon Antibody; IHC; Unconjugated

View related series

Accession#:P01275 GCG Gene ID:2641 Glucagon

Basic Description

Product Name	Recombinant Glukagon Antibody - Primary antibody, specific to Human, IgG
Synonyms	GCG antibody
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.3 mg/mL
Host species	Rabbit
Specificity	Human
Immunogen	Synthetic peptide within Human Glucagon aa 50-150 (N terminal). The exact sequence is proprietary.
Positive Control	IHC: Human pancreas tissue
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Recombinant antibody (EP3070) to Glukagon, could be used for IHC and so on. Application: IHC: 1/100-1/200 Purity Protein A purified Relevance Glukagon is a hormone that is secreted by alpha cells in the pancreas. Glukagon antagonizes insulin by converting glycogen to glucose in the liver and increasing blood sugar levels. Glukagon-like peptide 1 (GLP1), Glukagon-like peptide 2 (GLP2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are in the Glukagons hormone family. GLP1 is a transmitter in the central nervous system that regulates feeding and drinking behavior. GLP2 stimulates intestinal epithelial growth.

Product Properties

Isotype	IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.3 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Associated Targets

GATA4 Tbio Transcription factor GATA-4 0 Activities

Discover Target: GATA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GCG Tchem Glucagon 0 Activities

Discover Target: GCG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Dilution info

IHC

1/100 - 1/200

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0700717	Certificate of Analysis	Apr 25, 2024	Ab105544
ZJ23F0700718	Certificate of Analysis	Apr 25, 2024	Ab105544

References

1. Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC. (1983) Exon duplication and divergence in the human preproglucagon gene.. Nature, 304 (5924): (368-71). [PMID:6877358]
2. Rouillé Y, Bianchi M, Irminger JC, Halban PA. (1997) Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon.. FEBS Lett, 413 (1): (119-23). [PMID:9287128]
3. Bonic A, Mackin RB. (2003) Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment.. Protein Expr Purif, 28 (1): (15-24). [PMID:12651102]
4. Kim RM, Chang J, Lins AR, Brady E, Candelore MR, Dallas-Yang Q, Ding V, Dragovic J, Iliff S, Jiang G, Mock S, Qureshi S, Saperstein R, Szalkowski D, Tamvakopoulos C, Tota L, Wright M, Yang X, Tata JR, Chapman K, Zhang BB, Parmee ER.. (2008) Discovery of potent, orally active benzimidazole glucagon receptor antagonists.. Bioorg Med Chem Lett, 18 (13): (3701-3705). [PMID:18539028]
5. Orskov, C C, Bersani, M M, Johnsen, A H AH, Højrup, P P and Holst, J J JJ.. (1989) Complete sequences of glucagon-like peptide-1 from human and pig small intestine.. The Journal of biological chemistry, (5): [PMID:2753890]
6. Drucker, D J DJ and Asa, S S.. (1988) Glucagon gene expression in vertebrate brain.. The Journal of biological chemistry, (25): [PMID:2901414]
7. White, J W JW and Saunders, G F GF.. (1986) Structure of the human glucagon gene.. Nucleic acids research, (25): [PMID:3725587]
8. Orskov, C C, Wettergren, A A and Holst, J J JJ.. (1993) Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable.. Diabetes, [PMID:8482423]
9. Sturm, N S NS and 7 more authors.. (1998) Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.. Journal of medicinal chemistry, (16): [PMID:9667960]
10. and Drucker DJ.. (1999) Glucagon-like Peptide 2.. Trends in endocrinology and metabolism: TEM, [PMID:10322410]
11. Kieffer, T J TJ and Habener, J F JF.. (1999) The glucagon-like peptides.. Endocrine reviews, [PMID:10605628]
12. Chang, Xiaoqing X, Keller, Danielle D, O'Donoghue, Seán I SI and Led, Jens J JJ.. (2002) NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer.. FEBS letters, (27): [PMID:11943215]
13. Thomsen, J J, Kristiansen, K K, Brunfeldt, K K and Sundby, F F.. (1972) The amino acid sequence of human glucagon.. FEBS letters, (1): [PMID:11946536]
14. and Drucker, Daniel J DJ.. (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis.. Molecular endocrinology (Baltimore, Md.), [PMID:12554744]
15. Jiang, Guoqiang G and Zhang, Bei B BB.. (2003) Glucagon and regulation of glucose metabolism.. American journal of physiology. Endocrinology and metabolism, [PMID:12626323]
16. Ying, Jinfa J, Ahn, Jung-Mo JM, Jacobsen, Neil E NE, Brown, Michael F MF and Hruby, Victor J VJ.. (2003) NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles.. Biochemistry, (18): [PMID:12627948]
17. Cohen, Mark A MA and 8 more authors.. (2003) Oxyntomodulin suppresses appetite and reduces food intake in humans.. The Journal of clinical endocrinology and metabolism, [PMID:14557443]
18. Tadokoro, R R and 5 more authors.. (2003) Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants.. Acta paediatrica (Oslo, Norway : 1992), [PMID:14632334]
19. Brubaker, Patricia L PL and Anini, Younes Y.. (2003) Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.. Canadian journal of physiology and pharmacology, [PMID:14719035]
20. Hillier, Ladeana W LW and 121 more authors.. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature, (7): [PMID:15815621]
21. Ellingsgaard, Helga H and 20 more authors.. (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.. Nature medicine, (30): [PMID:22037645]

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