Recombinant; Rabbit anti Human GNAQ Antibody; WB, IHC; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab105911-10μl | 10μl | In stock | $66.90 | |
| Ab105911-50μl | 50μl | In stock | $199.90 | |
| Ab105911-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab105911-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,799.90 |
Recombinant; Rabbit anti Human GNAQ Antibody; WB, IHC; Unconjugated
| Product Name | Recombinant GNAQ Antibody - Primary antibody, specific to GNAQ, Rabbit IgG |
|---|---|
| Synonyms | CMAL|CMC1|G-ALPHA-q|GAQ|SWS|CMC1 antibody|G alpha Q antibody|G protein alpha Q antibody|G protein subunit alpha q antibody|G-ALPHA-q antibody|GAQ antibody|GNAQ antibody|GNAQ_HUMAN antibody|guanine nucleotide binding protein (G protein), q polypeptide anti |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.6 mg/mL |
| Host species | Rabbit |
| Specificity | GNAQ |
| Immunogen | Recombinant protein of human GNAQ (AA 2-359) |
| Positive Control | WB: K562, HEK293, Hep G2 and A549 cell lysates. IHC: Human breast cancer tissue. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description |
Rabbit anti Human GNAQ Antibody, Recombinant, could be used for WB, IHC and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Antigen affinity purified |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant GNAQ Antibody (Ab105911) - Western Blot
All lanes: Recombinant GNAQ Antibody (Ab105911) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 42 kDa
Observed band size: 38 kDa
Exposure time: 5.6 s
Recombinant GNAQ Antibody (Ab105911) - IHC
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant GNAQ Antibody (Ab105911). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50 - 1/100 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0303295 | Certificate of Analysis | Mar 15, 2024 | Ab105911 |
| ZJ24F0303296 | Certificate of Analysis | Mar 15, 2024 | Ab105911 |
| 1. Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK.. (2014) Development of inhibitors of heterotrimeric Gαi subunits.. Bioorg Med Chem, 22 (13): (3423-3434). [PMID:24818958] |
| 2. Lesch, K P KP and Manji, H K HK.. (1992) Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.. Biological psychiatry, (1): [PMID:1333286] |
| 3. Thomas, C P CP, Dunn, M J MJ and Mattera, R R.. (1995) Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.. The Biochemical journal, (15): [PMID:7492305] |
| 4. Chen, B B, Leverette, R D RD, Schwinn, D A DA and Kwatra, M M MM.. (1996) Human G(alpha q): cDNA and tissue distribution.. Biochimica et biophysica acta, (11): [PMID:8664309] |
| 5. Dong, Q Q and 8 more authors.. (1995) Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.. Genomics, (10): [PMID:8825633] |
| 6. Johnson, G J GJ, Leis, L A LA and Dunlop, P C PC.. (1996) Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.. The Biochemical journal, (15): [PMID:8836152] |
| 7. Gabbeta, J J, Dhanasekaran, N N and Rao, A K AK.. (1998) G alpha q cDNA sequence from human platelets.. Thrombosis research, (1): [PMID:9700850] |
| 8. Rochdi, Moulay Driss MD and 5 more authors.. (2002) Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50).. The Journal of biological chemistry, (25): [PMID:12193606] |
| 9. Humphray, S J SJ and 147 more authors.. (2004) DNA sequence and analysis of human chromosome 9.. Nature, (27): [PMID:15164053] |
| 10. Yeh, Jiunn-chern JC, Otte, Laura A LA and Frangos, John A JA.. (2008) Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.. Biochemistry, (26): [PMID:18672896] |
| 11. Van Raamsdonk, Catherine D CD and 8 more authors.. (2009) Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.. Nature, (29): [PMID:19078957] |
| 12. Wang, Y Y and 9 more authors.. (2012) Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity.. Scandinavian journal of immunology, [PMID:21923740] |
| 13. Murali, Rajmohan R, Wiesner, Thomas T, Rosenblum, Marc K MK and Bastian, Boris C BC.. (2012) GNAQ and GNA11 mutations in melanocytomas of the central nervous system.. Acta neuropathologica, [PMID:22307269] |
| 14. Shirley, Matthew D MD and 9 more authors.. (2013) Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ.. The New England journal of medicine, (23): [PMID:23656586] |
| 15. Alvarez-Curto, Elisa and 6 more authors.. (2016) Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.. The Journal of biological chemistry, (30): [PMID:27852822] |
