Recombinant Human 4-1BB/TNFRSF9 Protein, >90% (SDS-PAGE), high purity
ActiBioPure™
Animal Free
Azide Free
Bioactive
Carrier Free
≥90%(SDS-PAGE)
Features and benefits
Expression System: HEK293
Protein Tag: C-His
Bioactivity: Measured by its binding ability in a functional ELISA. Human 4-1BB/TNFRSF9 (rp169624) at 1.0 μg/mL can bind Urelumab (anti-TNFRSF9) (Ab170654) with the EC50 of 47.08 ng/mL.
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10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
rp169624-50μg
50μg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
rp169624-100μg
100μg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
rp169624-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.
Measured by its binding ability in a functional ELISA. Human 4-1BB/TNFRSF9 (rp169624) at 1.0 μg/mL can bind Urelumab (anti-TNFRSF9) (Ab170654) with the EC50 of 47.08 ng/mL.
27.8-38.6 kDa, under reducing conditions; 28.4-37.9 kDa, under non-reducing conditions
Images
Recombinant Human 4-1BB/TNFRSF9 Protein (rp169624) - ELISA Measured by its binding ability in a functional ELISA. Human 4-1BB/TNFRSF9 (rp169624) at 1.0 μg/mL can bind Urelumab (anti-TNFRSF9) (Ab170654) with the EC₅₀ of 47.08 ng/mL.
Recombinant Human 4-1BB/TNFRSF9 Protein (rp169624) - SDS-PAGE 3 μg/lane of Recombinant Human 4-1BB/TNFRSF9 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 27.8-38.6 kDa under reducing conditions and 28.4-37.9 kDa under non-reducing conditions.
Product Specifications
Form
Lyophilized
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20°C for 1 year. Avoid freeze / thaw cycle.
Certificates
Certificate of Analysis(COA)
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