Bioactivity: Measured by its ability to cleave a peptide substrate, benzoyl-AR-OH. The product, Arg, is reacted with ortho-phthaldialdehyde (OPA) to form a fluorescent molecule. The specific activity is >12,000 pmol/min/µg, as measured under the described conditions.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp144654
Grouped product items
SKU
Size
Availability
Price
Qty
rp144654-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
rp144654-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
rp144654-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
rp144654-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Measured by its ability to cleave a peptide substrate, benzoyl-AR-OH. The product, Arg, is reacted with ortho-phthaldialdehyde (OPA) to form a fluorescent molecule. The specific activity is >12,000 pmol/min/µg, as measured under the described conditions.
1.Manser, E E and 6 more authors.. (1990) Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.. The Biochemical journal, (15):[PMID:2334405]
2.Utsunomiya, N N and 5 more authors.. (1998) Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.. Diabetologia, [PMID:9662053]
3.Lee, Terence K TK and 13 more authors.. (2011) An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.. The Journal of clinical investigation, [PMID:21285511]
4.Liew, Chong Wee CW and 16 more authors.. (2014) Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.. Proceedings of the National Academy of Sciences of the United States of America, (3):[PMID:24843127]
5.Lee, Terence K TK and 13 more authors.. (2019) An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.. The Journal of clinical investigation, (18):[PMID:30882370]
6.Durmaz, Asude and 9 more authors.. (2021) A New Cause of Obesity Syndrome Associated with a Mutation in the Carboxypeptidase Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism. Journal of clinical research in pediatric endocrinology, (26):[PMID:32936766]
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