Bioactivity: Measured by its ability to cleave carnosine ( beta -Ala-L-His) in a two-step assay. The specific activity is >250 pmol/min/µg, as measured under the described conditions.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp144491
Grouped product items
SKU
Size
Availability
Price
Qty
rp144491-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
rp144491-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$419.90
rp144491-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$669.90
rp144491-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).
Measured by its ability to cleave carnosine ( beta -Ala-L-His) in a two-step assay. The specific activity is >250 pmol/min/µg, as measured under the described conditions.
1.Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al.. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res, 13 (10):(2265-70). [PMID:12975309][10.1021/op500134e]
2.Lenney, J F JF, Peppers, S C SC, Kucera, C M CM and Sjaastad, O O.. (1983) Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine.. Clinica chimica acta; international journal of clinical chemistry, (15):[PMID:6616870]
3.Lenney, J F JF and 5 more authors.. (1982) Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.. Clinica chimica acta; international journal of clinical chemistry, (18):[PMID:7116644]
4.Teufel, Michael M and 15 more authors.. (2003) Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.. The Journal of biological chemistry, (21):[PMID:12473676]
5.Janssen, Bart B and 24 more authors.. (2005) Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.. Diabetes, [PMID:16046297]
6.Nusbaum, Chad C and 54 more authors.. (2005) DNA sequence and analysis of human chromosome 18.. Nature, (22):[PMID:16177791]
7.Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
8.Veiga-da-Cunha, Maria M, Chevalier, Nathalie N, Stroobant, Vincent V, Vertommen, Didier D and Van Schaftingen, Emile E.. (2014) Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.. The Journal of biological chemistry, (11):[PMID:24891507]
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