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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
rp144491-10μg | 10μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $139.90 | |
rp144491-50μg | 50μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $419.90 | |
rp144491-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $669.90 | |
rp144491-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,899.90 |
Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-10*His tag, 28-507 aa
Product Name | Recombinant Human Carnosine Dipeptidase 1 Protein |
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Synonyms | Carnosine dipeptidase 1 | CNDP dipeptidase 1 | EC 3.4.13.20 | Glutamate carboxypeptidase-like protein 2 | Serum carnosinase | Carnosinase 1 | beta-Ala-His dipeptidase | carnosine dipeptidase 1 (metallopeptidase M20 family) | Carnosine Dipeptidase 1 | CN1M |
Grade | ActiBioPure™, Animal Free, Bioactive, Carrier Free |
Product Description | Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine). |
Specifications & Purity | ActiBioPure™, Bioactive, Animal Free, Carrier Free, ≥95%(SDS-PAGE) |
Bioactivity | Measured by its ability to cleave carnosine ( beta -Ala-L-His) in a two-step assay. The specific activity is >250 pmol/min/µg, as measured under the described conditions. |
Endotoxin Concentration | <0.1 EU/μg |
Expression System | HEK293 |
Species | Human |
Amino Acids | 28-507 aa |
Sequence | PSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIESDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGSDPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAFRALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAITYGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVVPLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPGTKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIANIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQNEKINRWNYIEGTKLFAAFFLEMAQLHHHHHHHHHHH |
Protein Tag | C-10His |
Accession # | Q96KN2 |
Predicted molecular weight | 55 kDa |
SDS-PAGE | 65 kDa, under reducing conditions |
Form | Liquid |
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Reconstitution | Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml. |
Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle. |
1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al.. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res, 13 (10): (2265-70). [PMID:12975309] [10.1021/op500134e] |
2. Lenney, J F JF, Peppers, S C SC, Kucera, C M CM and Sjaastad, O O.. (1983) Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine.. Clinica chimica acta; international journal of clinical chemistry, (15): [PMID:6616870] |
3. Lenney, J F JF and 5 more authors.. (1982) Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.. Clinica chimica acta; international journal of clinical chemistry, (18): [PMID:7116644] |
4. Teufel, Michael M and 15 more authors.. (2003) Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.. The Journal of biological chemistry, (21): [PMID:12473676] |
5. Janssen, Bart B and 24 more authors.. (2005) Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.. Diabetes, [PMID:16046297] |
6. Nusbaum, Chad C and 54 more authors.. (2005) DNA sequence and analysis of human chromosome 18.. Nature, (22): [PMID:16177791] |
7. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952] |
8. Veiga-da-Cunha, Maria M, Chevalier, Nathalie N, Stroobant, Vincent V, Vertommen, Didier D and Van Schaftingen, Emile E.. (2014) Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.. The Journal of biological chemistry, (11): [PMID:24891507] |