| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| rp145581-10μg | 10μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 | |
| rp145581-50μg | 50μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $329.90 | |
| rp145581-100μg | 100μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $599.90 | |
| rp145581-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,999.90 |
Animal Free, >97%(SDS-PAGE, HPLC), Active, E.coli, No tag, 24-97 aa
| Product Name | Recombinant Human CCL11/Eotaxin Protein, ＞97%(SDS-PAGE, HPLC), high purity |
|---|---|
| Synonyms | C-C motif chemokine 11; CCL11; chemokine (C-C motif) ligand 11; Eosinophil chemotactic protein; Eotaxin; eotaxin-1; MGC22554; SCYA11Small-inducible cytokine A11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); SCYA11 |
| Grade | ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High performance |
| Product Description | Purity > 97 % by SDS-PAGE and HPLC analyses.Endotoxin level is <1 EU/μg Function Human CCL11 is belonging to the CC chemokine family. It is encoded by the gene CCL11. CCL11 was first purified from bronchoalveolar lavage fluid of guinea pigs. It was a strong and specific eosinophil chemoattractant in vitro. It can directly chemotactic for eosinophils, but not for monocytes or neutrophils. CCR3 has been identified to be a specific CCL11 receptor.In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. |
| Specifications & Purity | ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥97%(SDS-PAGE&HPLC) |
| Purity | ＞97%(SDS-PAGE, HPLC) |
| Bioactivity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml. |
| Endotoxin Concentration | ＜1 EU/μg |
| Expression System | E.coli |
| Species | Human |
| Amino Acids | 24-97 aa |
| Sequence | GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP |
| Protein Tag | No tag |
| Accession # | P51671 |
| Predicted molecular weight | 8.4 kDa |
Recombinant Human CCL11/Eotaxin Protein (rp145581)-Protein Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/mL.
Recombinant Human CCL11/Eotaxin Protein (rp145581)-SDS-PAGE
Recombinant Human CCL11/Eotaxin Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a single band at 9.2 kDa.
| Form | Lyophilized |
|---|---|
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportio |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ℃ as supplied. 1 month, 2 to 8 ℃ under sterile conditions after reconstitution. 3 months, -20 to -70 ℃ under sterile conditions after reconstitu |
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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F0600341 | Certificate of Analysis | Mar 26, 2024 | rp145581 |
| ZJ23F0600342 | Certificate of Analysis | Mar 26, 2024 | rp145581 |
| ZJ23F0600343 | Certificate of Analysis | Mar 26, 2024 | rp145581 |
| 1. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O. (1996) Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.. J Biol Chem, 271 (13): (7725-30). [PMID:8631813] |
| 2. Garcia-Zepeda, E A EA and 5 more authors.. (1996) Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.. Nature medicine, [PMID:8597956] |
| 3. Ponath, P D PD and 11 more authors.. (1996) Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.. The Journal of clinical investigation, (1): [PMID:8609214] |
| 4. Bartels, J J and 6 more authors.. (1996) Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.. Biochemical and biophysical research communications, (23): [PMID:8780731] |
| 5. Garcia-Zepeda, E A EA and 5 more authors.. (1997) Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.. Genomics, (1): [PMID:9169149] |
| 6. Hein, H H and 5 more authors.. (1997) Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.. Biochemical and biophysical research communications, (28): [PMID:9299399] |
| 7. Noso, N N and 5 more authors.. (1998) Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.. European journal of biochemistry, (1): [PMID:9578468] |
| 8. Crump, M P MP, Rajarathnam, K K, Kim, K S KS, Clark-Lewis, I I and Sykes, B D BD.. (1998) Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.. The Journal of biological chemistry, (28): [PMID:9712872] |
