| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| rp143978-10μg | 10μg | In stock | $139.90 | |
| rp143978-50μg | 50μg | In stock | $389.90 | |
| rp143978-100μg | 100μg | In stock | $539.90 | |
| rp143978-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,899.90 |
Animal Free, >95%(SDS-PAGE), Active, 293F, His tag, 43-300 aa
| Product Name | Recombinant Human CD38 Protein, ＞95%(SDS-PAGE), high purity |
|---|---|
| Synonyms | 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl Cyclase; ADP-ribosyl cyclase/cyclic ADP-r |
| Grade | ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free |
| Product Description | Purity |
| Specifications & Purity | ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE) |
| Purity | ＞95%(SDS-PAGE) |
| Bioactivity | Immobilized Human CD38 Protein at 1μg/mL (100 μL/well) can bind CD38 Rabbit pAb with a linear range of 0.244-3.2 ng/mL. |
| Endotoxin Concentration | ＜0.1 EU/μg |
| Expression System | HEK293 |
| Species | Human |
| Amino Acids | 43-300 aa |
| Sequence | VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCT |
| Protein Tag | C-His |
| Accession # | P28907 |
| Predicted molecular weight | 47 kDa |
| SDS-PAGE | 43.0 kDa, under reducing conditions; 43.0 kDa, under non-reducing conditions. |
Recombinant Human CD38 Protein (rp143978) - Protein Bioactivity
Immobilized Human CD38 Protein (rp143978) at 1μg/mL can bind CD38 Antibody with a linear range of 0.244 - 3.2 ng/mL.
Recombinant Human CD38 Protein (rp143978) - SDS-PAGE
3 μg/lane of Recombinant Human CD38 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 43.0 kDa.
| Form | Lyophilized |
|---|---|
| Reconstitution | Reconstitute in sterile H2O to a concentration of 0.1-0.5 mg/ml. |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at ﹣20 ~﹣80℃ for more than 1 year |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0102338 | Certificate of Analysis | Jan 30, 2024 | rp143978 |
| ZJ24F0102337 | Certificate of Analysis | Jan 30, 2024 | rp143978 |
| ZJ24F0102335 | Certificate of Analysis | Jan 30, 2024 | rp143978 |
| 1. de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC, Oomen LA, Peipp M, Valerius T, Slootstra JW et al.. (2011) Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.. J Immunol, 186 (3): (1840-8). [PMID:21187443] |
| 2. Jackson DG, Bell JI. (1990) Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.. J Immunol, 144 (7): (2811-5). [PMID:2319135] |
| 3. Isabelle Kuhn,Esther Kellenberger,Fatouma Said-Hassane,Pascal Villa,Didier Rognan,Annelise Lobstein,Jacques Haiech,Marcel Hibert,Francis Schuber,Hélène Muller-Steffner. (2010-10-19) Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.. Bioorganic & medicinal chemistry, 18 ((22)): (7900-7910). [PMID:20951593] |
| 4. Swarbrick JM, Graeff R, Zhang H, Thomas MP, Hao Q, Potter BV.. (2014) Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.. J Med Chem, 57 (20): (8517-8529). [PMID:25226087] |
| 5. Jacques SA, Kuhn I, Koniev O, Schuber F, Lund FE, Wagner A, Muller-Steffner H, Kellenberger E.. (2015) Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.. J Med Chem, 58 (8): (3582-3592). [PMID:25803425] |
| 6. Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG, Shearer TW, Shewchuk LM, Smalley TL, Stewart EL, Stuart JD, Ulrich JC.. (2015) Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.. J Med Chem, 58 (17): (7021-7056). [PMID:26267483] |
| 7. Deaton DN, Haffner CD, Henke BR, Jeune MR, Shearer BG, Stewart EL, Stuart JD, Ulrich JC.. (2018) 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships.. Bioorg Med Chem, 26 (8): (2107-2150). [PMID:29576271] |
| 8. States, D J DJ, Walseth, T F TF and Lee, H C HC.. (1992) Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.. Trends in biochemical sciences, [PMID:1471258] |
| 9. Tohgo, A A and 8 more authors.. (1994) Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.. The Journal of biological chemistry, (18): [PMID:7961800] |
| 10. Takasawa, S S and 7 more authors.. (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.. The Journal of biological chemistry, (15): [PMID:8253715] |
| 11. Nata, K K and 9 more authors.. (1997) Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.. Gene, (28): [PMID:9074508] |
| 12. Yagui, K K and 13 more authors.. (1998) A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.. Diabetologia, [PMID:9754820] |
| 13. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE.. (2004) An unappreciated role for RNA surveillance.. Genome biology, [PMID:14759258] |
| 14. Liu, Qun Q and 5 more authors.. (2005) Crystal structure of human CD38 extracellular domain.. Structure (London, England : 1993), [PMID:16154090] |
| 15. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973] |
