Recombinant Human CD46 Protein, ≥95% (SDS-PAGE), high purity

Features and benefits
  • Expression System: HEK293
  • Accession #: P15529
  • Protein Tag: C-His
  • Bioactivity: Immobilized Human CD46 Protein at 1μg/mL (100 μL/well) can bind CD46 antibody with a linear range of 0.2-3.8 ng/mL.
  • Endotoxin Concentration: <0.1 EU/μg
Item Number
rp144024
Grouped product items
SKUSizeAvailabilityPrice Qty
rp144024-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
rp144024-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
rp144024-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
rp144024-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90

Animal Free, ≥95% (SDS-PAGE), Active, HEK293, C-His tag, 35-328 aa

Basic Description

Product NameRecombinant Human CD46 Protein, ≥95% (SDS-PAGE), high purity
SynonymsAHUS2 | Antigen defined by monoclonal antibody TRA 2 10 | Antigen identified by monoclonal antibody TRA 2 10 | CD46 | CD46 antigen | CD46 antigen complement regulatory protein | CD46 molecule | CD46 molecule complement regulatory protein | Complement memb
GradeActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free
Product Description

Purity

≥95% (SDS-PAGE)

Endotoxin level

<0.1 EU/μg

Function

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Specifications & PurityActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
Purity≥95% (SDS-PAGE)
BioactivityImmobilized Human CD46 Protein at 1μg/mL (100 μL/well) can bind CD46 antibody with a linear range of 0.2-3.8 ng/mL.
Endotoxin Concentration<0.1 EU/μg
Expression SystemHEK293
SpeciesHuman
Amino Acids35-328 aa
SequenceCEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDHHHHHH
Protein TagC-His
Accession #P15529
Predicted molecular weight33 kDa
SDS-PAGE55-60 kDa,under reducing conditions

Images

Recombinant Human CD46 Protein (rp144024) - Protein Bioactivity
Immobilized Recombinant Human CD46 Protein (rp144024) at 1.0 μg/mL can bind CD46 antibody with a linear range of 0.2 - 3.8 ng/mL.

Recombinant Human CD46 Protein (rp144024) - SDS-PAGE
3 μg/lane of Recombinant Human CD46 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 55.0 kDa.


Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404954Certificate of AnalysisApr 30, 2024 rp144024
ZJ24F0404953Certificate of AnalysisApr 30, 2024 rp144024
ZJ24F0404952Certificate of AnalysisApr 30, 2024 rp144024

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