Bioactivity: Measured by its binding ability in a functional ELISA. When rhIGF-II R is immobilized at 2 μg/mL (100 µL/well), the concentration of rhCREG that produces 50% of the optimal binding response is found to be approximately 2-10 ng/mL.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp144694
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Size
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rp144694-10μg
10μg
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$89.90
rp144694-50μg
50μg
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$249.90
rp144694-100μg
100μg
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$399.90
rp144694-1mg
1mg
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Function May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
Measured by its binding ability in a functional ELISA. When rhIGF-II R is immobilized at 2 μg/mL (100 µL/well), the concentration of rhCREG that produces 50% of the optimal binding response is found to be approximately 2-10 ng/mL.
1.Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al.. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res, 13 (10):(2265-70). [PMID:12975309][10.1021/op500134e]
2.Veal, E E, Eisenstein, M M, Tseng, Z H ZH and Gill, G G.. (1998) A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.. Molecular and cellular biology, [PMID:9710587]
3.Veal, E E, Groisman, R R, Eisenstein, M M and Gill, G G.. (2000) The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells.. Oncogene, (20):[PMID:10815803]
4.Di Bacco, Alessandra A and Gill, Grace G.. (2003) The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor.. Oncogene, (21):[PMID:12934103]
5.Zhang, Zemin Z and Henzel, William J WJ.. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein science : a publication of the Protein Society, [PMID:15340161]
6.Sacher, Michael M and 6 more authors.. (2005) The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.. Proceedings of the National Academy of Sciences of the United States of America, (20):[PMID:16344469]
7.Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18):[PMID:16710414]
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