Recombinant Human CXCL7/PBP Protein, >97%( SDS-PAGE and HPLC), high purity

Features and benefits
  • Expression System: E. coli
  • Accession #: P02775
  • Protein Tag: No tag
  • Bioactivity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.
  • Endotoxin Concentration: <0.1 EU/μg
Item Number
rp144868
Grouped product items
SKUSizeAvailabilityPrice Qty
rp144868-10μg
10μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
rp144868-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$429.90
rp144868-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$769.90
rp144868-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90

Animal Free, >97%( SDS-PAGE and HPLC), Active, E.coli, No tag, 59-128 aa

Basic Description

Product NameRecombinant Human CXCL7/PBP Protein, >97%( SDS-PAGE and HPLC), high purity
SynonymsBeta-TG; Connective tissue-activating peptide III; CTAP III; CTAP3CTAP-III; CTAPIII; CXC chemokine ligand 7; C-X-C motif chemokine 7; CXCL7; CXCL7b-TG1; LA-PF4; LDGFTC1; Leukocyte-derived growth factor; Low-affinity platelet factor IV; Macrophage-derived
GradeActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description

Purity
>97% SDS-PAGE and HPLC analyses..

Function
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

Post-translational
Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)). Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.

Specifications & PurityActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥97%(SDS-PAGE&HPLC)
Purity>97%( SDS-PAGE and HPLC)
BioactivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.
Endotoxin Concentration<0.1 EU/μg
Expression SystemE. coli
SpeciesHuman
Amino Acids59-128 aa
SequenceAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD
Protein TagNo tag
Accession #P02775
Predicted molecular weight7.6 kDa
SDS-PAGE7.6 kDa

Images

Recombinant Human CXCL7/PBP Protein (rp144868)-Protein Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/mL.

Recombinant Human CXCL7/PBP Protein (rp144868)-SDS-PAGE
Recombinant Human CXCL7/PBP Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 7.6 kDa under reducing conditions and 9.2-14.4 kDa under non-reducing conditions.

Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Stability And StorageUpon delivery aliquot, Store at -20°C, Avoid freeze/thaw cycles. This product is an active protein and may elicit a biological response in vivo, handle with caution.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ23F0600422Certificate of AnalysisMar 26, 2024 rp144868
ZJ23F0600423Certificate of AnalysisMar 26, 2024 rp144868
ZJ23F0600424Certificate of AnalysisMar 26, 2024 rp144868

Related Documents

References

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