Recombinant Human Cystatin C Protein

Features and benefits
  • Expression System: E. coli
  • Protein Tag: N-His
  • Bioactivity: Testing in progress
  • Endotoxin Concentration: <1.0 EU/μg
Item Number
rp169603
Grouped product items
SKUSizeAvailabilityPrice Qty
rp169603-10μg (Trial Size)
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10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
rp169603-50μg
50μg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
rp169603-100μg
100μg
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$599.90
rp169603-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,999.90

Carrier Free, ≥95% (SDS-PAGE), E. coli, N-His tag, 27-146 aa

Basic Description

Product NameRecombinant Human Cystatin C Protein
GradeCarrier Free
Product Description

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description:
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein that has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression.

Specifications & PurityCarrier Free, ≥95%(SDS-PAGE)
BioactivityTesting in progress
Endotoxin Concentration<1.0 EU/μg
Expression SystemE. coli
Amino Acids27-146 aa
SequenceMGSSHHHHHHSSGLVPRGSMGSSHHHHHHSSGLVPRGSSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
Protein TagN-His
Predicted molecular weight17.4 kDa
SDS-PAGE17.1 kDa, under reducing conditions; 17.1 kDa, under non-reducing conditions

Images

Recombinant Human Cystatin C Protein (rp169603) - SDS-PAGE
2 μg/lane of Recombinant Human Cystatin C Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 17.1 kDa.

Product Specifications

FormLiquid
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20°C for 1 year. Avoid freeze / thaw cycle.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0506345Certificate of AnalysisMay 31, 2024 rp169603
ZJ24F0506341Certificate of AnalysisMay 31, 2024 rp169603
ZJ24F0506340Certificate of AnalysisMay 31, 2024 rp169603

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