Recombinant Human EPCR Protein, ≥95% (SDS-PAGE), high purity

Features and benefits
  • Expression System: HEK293
  • Accession #: Q9UNN8
  • Protein Tag: C-His
  • Bioactivity: When human Activated Protein C (APC) is immobilized at 3 μg/mL, 100 μL/well, Recombinant Human EPCR binds with an ED50 of 1-5 μg/mL.
  • Endotoxin Concentration: <0.1 EU/μg
Item Number
rp145594
Grouped product items
SKUSizeAvailabilityPrice Qty
rp145594-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
rp145594-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
rp145594-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$449.90
rp145594-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90

Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 18-210 aa

Basic Description

Product NameRecombinant Human EPCR Protein, ≥95% (SDS-PAGE), high purity
GradeActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free
Product Description

Purity
≥95% SDS-PAGE.
Endotoxin level
<0.1 EU/µg
Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Specifications & PurityActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
Purity≥95% (SDS-PAGE)
BioactivityWhen human Activated Protein C (APC) is immobilized at 3 μg/mL, 100 μL/well, Recombinant Human EPCR binds with an ED50 of 1-5 μg/mL.
Endotoxin Concentration<0.1 EU/μg
Expression SystemHEK293
SpeciesHuman
Amino Acids18-210 aa
SequenceSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSHHHHHH
Protein TagC-His
Accession #Q9UNN8
Predicted molecular weight22.8 kDa
SDS-PAGE36.0 - 40.0 kDa, under reducing conditions; 36.0 - 40.0 kDa, under non-reducing conditions.

Images

Recombinant Human EPCR Protein (rp145594) - Protein Bioactivity
Measured by its binding ability in a functional ELISA. When human Activated Protein C (APC) is immobilized at 3.0 μg/mL, Recombinant Human EPCR Protein (rp145594) binds with an ED ₅₀ of 3.5 μg/mL.

Recombinant Human EPCR Protein (rp145594) - SDS-PAGE
3 μg/lane of Recombinant Human EPCR Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 36.0 - 40.0 kDa.

Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0607345Certificate of AnalysisJun 28, 2024 rp145594
ZJ24F0607344Certificate of AnalysisJun 28, 2024 rp145594
ZJ24F0607343Certificate of AnalysisJun 28, 2024 rp145594

Related Documents

References

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7. Oganesyan, Vaheh V and 6 more authors..  (2002)  The crystal structure of the endothelial protein C receptor and a bound phospholipid..  The Journal of biological chemistry,    (12):   [PMID:12034704]
8. Castellino, Francis J FJ and 6 more authors..  (2002)  Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge..  Thrombosis and haemostasis,      [PMID:12353077]
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