Bioactivity: Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ER
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Protein Function:: ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ER
81.5-101.9 kDa, under reducing conditions; 74.3-99.3 kDa, under non-reducing conditions
Images
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - SDS-PAGE 3 μg/lane of Recombinant Human ErbB3/HER3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 81.5-101.9 kDa under reducing conditions and 74.3-99.3 kDa under non-reducing conditions.
Product Specifications
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20°C for 1 year. Avoid freeze / thaw cycle.
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