Basic Description

Product Name	Recombinant Human Estrogen Receptor alpha Protein
Synonyms	Estrogen Receptor alpha ; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1; ER; Era; ESR; ESRA; ESTRR; NR3A; 17/654 isoform; 7/819 2 isoform; 7/822 isoform; 8/901 isoform; 8*/941 isoform; DKFZp686N23123; ER; ER alpha; Era; E
Grade	Azide Free, Carrier Free
Product Description	Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： ER alpha (Estrogen receptor alpha; also Estradiol receptor and NR3A1) is a 65-70 kDa member of the NR3 subfamily, nuclear hormone receptor family of proteins. It is widely expressed, and serves as a strong activator of estrogen-responsive genes. ER alpha is normally quiescent and bound to heat-shock proteins and immunophilins. Following beta -estradiol binding, it becomes activated, either homodimerizes or heterodimerizes with ER beta, and binds to DNA with multiple coactivators. Human ER alpha is 595 amino acids (aa) in length. It contains a DNA binding region (aa 185-250), three NLSs (aa 256-260; 266-271; 299-303), a steroid-binding site (aa 351-543), a dimerization motif (aa 497-518), and an O-GlcNAc attachment around Thr575. Major phosphorylation sites exist at Tyr537, Ser167 and Ser118. Multiple splice forms exist. There is an 80 kDa isoform that shows a substitution (duplication) of aa 412-517 for Asp411, a second isoform with a deletion of aa 255-366, a third isoform with a deletion of aa 152-412, and a fourth isoform that shows a Thr substitution for aa 152-595. Human ER alpha is only 46% aa identical to human ER beta. Over aa 1-116, human ER alpha shares 85% aa identity with mouse ER alpha.
Specifications & Purity	Carrier Free, Azide Free, ≥90%(SDS-PAGE)
Endotoxin Concentration	＜1.0 EU/μg
Expression System	E. coli
Amino Acids	1-185 aa
Sequence	MHHHHHHMTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYC
Protein Tag	N-His
Predicted molecular weight	21.0 kDa
SDS-PAGE	24.8kDa and 47.1 kDa, reducing conditions; 24.8kDa and 47.1 kDa, non-reducing conditions

Images

Recombinant Human Estrogen Receptor alpha protein (rp175926) - SDS-PAGE
Recombinant Human Estrogen Receptor alpha protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing two bands at 24.8 and 47.1 kDa.

Product Specifications

Form	Lyophilized
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20°C for 1 year. Avoid freeze/thaw cycle.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ23F1101874	Certificate of Analysis	Dec 13, 2023	rp175926
ZJ23F1101873	Certificate of Analysis	Dec 13, 2023	rp175926
ZJ23R1100166	Certificate of Analysis	Nov 24, 2023	rp175926

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Cytokines Drug development Target Proteins Drug Targets Receptors Immune Checkpoints Cell Surface Markers Signaling Pathways

References

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235. Rubino, D D and 9 more authors.. (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.. Oncogene, (14): [PMID:9627117]
236. Montano, M M MM and 5 more authors.. (1999) An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.. Proceedings of the National Academy of Sciences of the United States of America, (8): [PMID:10359819]
237. Hunter, D S DS and 5 more authors.. (1999) Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium.. Cancer research, (1): [PMID:10397250]
238. Rogatsky, I I, Trowbridge, J M JM and Garabedian, M J MJ.. (1999) Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex.. The Journal of biological chemistry, (6): [PMID:10428798]
239. Schubert, E L EL, Lee, M K MK, Newman, B B and King, M C MC.. (1999) Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene and breast cancer susceptibility.. The Journal of steroid biochemistry and molecular biology, [PMID:10619354]
240. Klinge, C M CM, Kaur, K K and Swanson, H I HI.. (2000) The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.. Archives of biochemistry and biophysics, (1): [PMID:10620335]
241. Saville, B B and 7 more authors.. (2000) Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.. The Journal of biological chemistry, (25): [PMID:10681512]
242. Stoner, M M and 8 more authors.. (2000) Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.. The Journal of biological chemistry, (28): [PMID:10816575]
243. Becherini, L L and 10 more authors.. (2000) Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women.. Human molecular genetics, (12): [PMID:10942433]
244. Zhou, J J, Ng, S S, Adesanya-Famuiya, O O, Anderson, K K and Bondy, C A CA.. (2000) Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:10973921]
245. Tessier, C C and 6 more authors.. (2000) Estrogen receptors alpha and beta in rat decidua cells: cell-specific expression and differential regulation by steroid hormones and prolactin.. Endocrinology, [PMID:11014241]
246. Métivier, R R, Petit, F G FG, Valotaire, Y Y and Pakdel, F F.. (2000) Function of N-terminal transactivation domain of the estrogen receptor requires a potential alpha-helical structure and is negatively regulated by the A domain.. Molecular endocrinology (Baltimore, Md.), [PMID:11075817]
247. Benecke, A A, Chambon, P P and Gronemeyer, H H.. (2000) Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.. EMBO reports, [PMID:11265755]
248. Vadlamudi, R K RK and 6 more authors.. (2001) Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.. The Journal of biological chemistry, (12): [PMID:11481323]
249. Maggiolini, M M and 6 more authors.. (2001) Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.. Molecular pharmacology, [PMID:11502892]
250. Yahata, T T and 10 more authors.. (2001) Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.. Genes & development, (1): [PMID:11581164]
251. Métivier, R R, Penot, G G, Flouriot, G G and Pakdel, F F.. (2001) Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains.. Molecular endocrinology (Baltimore, Md.), [PMID:11682626]
252. Locci, P P and 8 more authors.. (2001) Synthesis and secretion of transforming growth factor-beta1 by human desmoid fibroblast cell line and its modulation by toremifene.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, [PMID:11747628]
253. Norris, John D JD, Fan, Daju D, Sherk, Andrea A and McDonnell, Donald P DP.. (2002) A negative coregulator for the human ER.. Molecular endocrinology (Baltimore, Md.), [PMID:11875103]
254. Fabian, C J CJ and Kimler, B F BF.. () Chemoprevention for high-risk women: tamoxifen and beyond.. The breast journal, [PMID:11906441]
255. and Dow, Karen Hassey KH.. (2002) Existing and emerging endocrine therapies for breast cancer.. Cancer nursing, [PMID:12080538]
256. Puddefoot, John R JR, Barker, Stewart S, Glover, Hilary R HR, Malouitre, Sylvanie D M SD and Vinson, Gavin P GP.. (2002) Non-competitive steroid inhibition of oestrogen receptor functions.. International journal of cancer, (1): [PMID:12209583]
257. Margeat, Emmanuel E and 5 more authors.. (2003) Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta.. Journal of molecular biology, (7): [PMID:12547192]
258. Li, Lei L, Haynes, M Page MP and Bender, Jeffrey R JR.. (2003) Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:12682286]
259. Liu, Xuemei X and 7 more authors.. (2003) Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.. Chemical research in toxicology, [PMID:12870885]
260. and Pasqualini, J R JR.. (2003) Differential effects of progestins on breast tissue enzymes.. Maturitas, (10): [PMID:14670645]
261. Ikeda, Kazuhiro K and 7 more authors.. (2004) Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.. Molecular endocrinology (Baltimore, Md.), [PMID:14764652]
262. Barletta, Frank F and 5 more authors.. (2004) Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.. Molecular endocrinology (Baltimore, Md.), [PMID:14963108]
263. Bu, Hengfu H and 7 more authors.. (2004) ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.. Biochemical and biophysical research communications, (23): [PMID:15047147]
264. Mérot, Yohann Y and 8 more authors.. (2004) The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.. The Journal of biological chemistry, (18): [PMID:15078875]
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267. del Río, Beatriz B and 5 more authors.. (2004) Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin.. The Journal of biological chemistry, (10): [PMID:15229223]
268. Rayala, Suresh K SK and 5 more authors.. (2005) Functional regulation of oestrogen receptor pathway by the dynein light chain 1.. EMBO reports, [PMID:15891768]
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270. Vereide, Anne Beate AB, Kaino, Turid T, Sager, Georg G, Arnes, Marit M and Ørbo, Anne A.. (2006) Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia.. Gynecologic oncology, [PMID:16325240]
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273. Farooqui, Mariya M and 5 more authors.. (2006) Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells.. Molecular cancer therapeutics, [PMID:16546975]
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275. Gururaj, Anupama E AE and 9 more authors.. (2006) MTA1, a transcriptional activator of breast cancer amplified sequence 3.. Proceedings of the National Academy of Sciences of the United States of America, (25): [PMID:16617102]
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283. Garcia-Segura, Luis M LM, Sanz, Amaya A and Mendez, Pablo P.. (2006) Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection.. Neuroendocrinology, [PMID:17124377]
284. Brama, Marina M and 10 more authors.. (2007) Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism.. Molecular and cellular endocrinology, (29): [PMID:17125913]
285. Yuri, Takashi T, Tsukamoto, Reiko R, Uehara, Norihisa N, Matsuoka, Yoichiro Y and Tsubura, Airo A.. () Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.. In vivo (Athens, Greece), [PMID:17203775]
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288. Dixon, Alexis A, Wells, Corinne C CC, Singh, Sandhya S, Babayan, Regina R and Maric, Christine C.. (2007) Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy.. American journal of nephrology, [PMID:17308373]
289. Yan, Jun J and 5 more authors.. (2007) Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.. Nucleic acids research, [PMID:17311814]
290. Baron, Sylvain S and 5 more authors.. (2007) Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene.. The Journal of biological chemistry, (20): [PMID:17317669]
291. Montero Girard, Guadalupe G and 11 more authors.. (2007) Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.. Breast cancer research : BCR, [PMID:17341305]
292. Ghebeh, Hazem H and 6 more authors.. (2007) Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells.. International journal of cancer, (15): [PMID:17415709]
293. Gururaj, Anupama E AE, Peng, Shaohua S, Vadlamudi, Ratna K RK and Kumar, Rakesh R.. (2007) Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).. Molecular endocrinology (Baltimore, Md.), [PMID:17505058]
294. Meyer, Rene R, Wolf, Siegmund S SS and Obendorf, Maik M.. (2007) PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.. The Journal of steroid biochemistry and molecular biology, [PMID:17587566]
295. Revankar, Chetana M CM and 8 more authors.. (2007) Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.. ACS chemical biology, (17): [PMID:17655271]
296. Eriksson, Maria M and 6 more authors.. (2007) The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain.. Biochemical and biophysical research communications, (14): [PMID:17658481]
297. Han, W-D WD and 11 more authors.. (2007) Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity.. Endocrine-related cancer, [PMID:17914104]
298. Molli, P R PR, Singh, R R RR, Lee, S W SW and Kumar, R R.. (2008) MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene.. Oncogene, (27): [PMID:17922032]
299. Nettles, Kendall W KW and 5 more authors.. (2008) CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.. Molecular endocrinology (Baltimore, Md.), [PMID:17932106]
300. Lambertini, Elisabetta E and 5 more authors.. (2008) ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts.. Journal of cellular physiology, [PMID:18247370]
301. Chen, Ming M, Ni, Jing J, Zhang, Yong Y, Muyan, Mesut M and Yeh, Shuyuan S.. (2008) ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.. The Prostate, (1): [PMID:18563714]
302. Maru, Benit S BS and 5 more authors.. (2009) Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity.. Bone, [PMID:18976723]
303. Amadasi, Alessio; Mozzarelli, Andrea; Meda, Clara; Maggi, Adriana and Cozzini, Pietro.. (2009) Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.. Chemical research in toxicology, [PMID:19063592]
304. Jayaraman, A and Pike, C J.. (2009) Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.. Journal of neuroendocrinology, [PMID:19094096]
305. Johnsen, Steven A SA and 13 more authors.. (2009) Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.. Cancer research, (1): [PMID:19117995]
306. Giamas, Georgios G and 9 more authors.. (2009) CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.. Nucleic acids research, [PMID:19339517]
307. Gionet, Nathalie N, Jansson, Deidre D, Mader, Sylvie S and Pratt, M A Christine MA.. (2009) NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells.. Journal of cellular biochemistry, (1): [PMID:19350539]
308. Stanisić, Vladimir V, Malovannaya, Anna A, Qin, Jun J, Lonard, David M DM and O'Malley, Bert W BW.. (2009) OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.. The Journal of biological chemistry, (12): [PMID:19383985]
309. Lappano, Rosamaria R and 12 more authors.. (2009) Structure-activity relationships of resveratrol and derivatives in breast cancer cells.. Molecular nutrition & food research, [PMID:19496085]
310. Zusev, Margalit and Benayahu, Dafna.. (2009) The regulation of MS-KIF18A expression and cross talk with estrogen receptor.. PloS one, (28): [PMID:19636373]
311. Li, Tingting T and 5 more authors.. (2009) SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway.. BMB reports, (31): [PMID:19712589]
312. Wortham, N C NC and 12 more authors.. (2009) The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.. Oncogene, (19): [PMID:19718048]
313. Vivacqua, Adele A and 8 more authors.. (2009) G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.. Molecular endocrinology (Baltimore, Md.), [PMID:19749156]
314. Bombail, Vincent V, Collins, Frances F, Brown, Pamela P and Saunders, Philippa T K PT.. (2010) Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.. Molecular and cellular endocrinology, (15): [PMID:19755138]
315. Brown, Julie J, Farquhar, Cindy C, Beck, James J, Boothroyd, Clare C and Hughes, Edward E.. (2009) Clomiphene and anti-oestrogens for ovulation induction in PCOS.. The Cochrane database of systematic reviews, (7): [PMID:19821295]
316. and Dang, ZhiChao Z.. (2010) Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.. Toxicology letters, (15): [PMID:19913605]
317. Koyama, Satoshi S and 12 more authors.. (2010) Repression of estrogen receptor beta function by putative tumor suppressor DBC1.. Biochemical and biophysical research communications, (12): [PMID:20074560]
318. Guyot, Romain R, Vincent, Séverine S, Bertin, Julie J, Samarut, Jacques J and Ravel-Chapuis, Patrick P.. (2010) The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.. BMC molecular biology, (15): [PMID:20078863]
319. Dulos, John J and 7 more authors.. (2010) Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta.. Arthritis research & therapy, [PMID:20497523]
320. Cyrus, Kedra K and 5 more authors.. (2010) Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs.. ChemMedChem, (5): [PMID:20512796]
321. Pradhan, Madhumita M, Bembinster, Leslie A LA, Baumgarten, Sarah C SC and Frasor, Jonna J.. (2010) Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.. The Journal of biological chemistry, (8): [PMID:20705611]
322. Dong, Xue-Yuan XY and 6 more authors.. (2010) ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.. The Journal of biological chemistry, (22): [PMID:20720010]
323. Shyu, Conrad; Cavileer, Timothy D; Nagler, James J and Ytreberg, F Marty.. (2011) Computational estimation of rainbow trout estrogen receptor binding affinities for environmental estrogens.. Toxicology and applied pharmacology, (1): [PMID:21075131]
324. Park, Yeomyung Y and 7 more authors.. (2011) Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.. Journal of molecular medicine (Berlin, Germany), [PMID:21104395]
325. Heldring, Nina N and 6 more authors.. (2011) Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.. Molecular endocrinology (Baltimore, Md.), [PMID:21330404]
326. Giamas, Georgios G and 16 more authors.. (2011) Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.. Nature medicine, [PMID:21602804]
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328. Pedram, Ali A, Razandi, Mahnaz M, Deschenes, Robert J RJ and Levin, Ellis R ER.. (2012) DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.. Molecular biology of the cell, [PMID:22031296]
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Recombinant Human Estrogen Receptor alpha Protein