Recombinant Human Fc epsilon RI alpha Protein, ≥95% (SDS-PAGE), high purity
ActiBioPure™
Animal Free
Azide Free
Bioactive
Carrier Free
≥95%(SDS-PAGE)
Features and benefits
Expression System: HEK293
Accession #: P12319
Protein Tag: C-His
Bioactivity: Immobilized FITC anti-human FcεRIα Antibody at 1μg/mL (25 μL/well) can bind Human Fc epsilon RI alpha with a linear range of 0.46-3.15 ng/mL.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp145872
Grouped product items
SKU
Size
Availability
Price
Qty
rp145872-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
rp145872-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
rp145872-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
rp145872-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
1.Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet JP, Capron M. (1994) High-affinity IgE receptor on eosinophils is involved in defence against parasites.. Nature, 367 (6459):(183-6). [PMID:8114916]
2.Padlan, E A EA and Helm, B A BA.. (1992) A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E.. Receptor, [PMID:1472946]
3.Shimizu, A A and 5 more authors.. (1988) Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2964640]
4.Kochan, J J, Pettine, L F LF, Hakimi, J J, Kishi, K K and Kinet, J P JP.. (1988) Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor.. Nucleic acids research, (25):[PMID:2967464]
5.Yagi, S S and 5 more authors.. (1994) High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product.. European journal of biochemistry, (1):[PMID:8125119]
6.Garman, S C SC, Wurzburg, B A BA, Tarchevskaya, S S SS, Kinet, J P JP and Jardetzky, T S TS.. (2000) Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.. Nature, (20):[PMID:10917520]
7.Garman, S C SC, Sechi, S S, Kinet, J P JP and Jardetzky, T S TS.. (2001) The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms.. Journal of molecular biology, (31):[PMID:11531339]
8.Beck, Lisa A LA, Marcotte, Gregory V GV, MacGlashan, Donald D, Togias, Alkis A and Saini, Sarbjit S.. (2004) Omalizumab-induced reductions in mast cell Fce psilon RI expression and function.. The Journal of allergy and clinical immunology, [PMID:15356552]
9.Mirkina, Irina I, Schweighoffer, Tamás T and Kricek, Franz F.. (2007) Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab.. Immunology letters, (15):[PMID:17368811]
10.Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1):[PMID:11752352]
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