Recombinant Human HAI-2A Protein

Features and benefits

Expression System: HEK293
Accession #: O43291
Protein Tag: C-10His
Bioactivity: Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <4.6 nM, as measured under the described conditions.
Endotoxin Concentration: <0.1 EU/μg

Item Number

rp146921

Grouped product items
SKU	Size	Availability	Price
rp146921-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
rp146921-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$409.90
rp146921-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$659.90
rp146921-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,939.90

Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-10*His tag, 1-197 aa

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Basic Description

Product Name	Recombinant Human HAI-2A Protein
Synonyms	HAI-2 \| Hepatocyte growth factor activator inhibitor type 2 \| Placental bikunin \| HAI-2A \| HAI2A \| Placental Bikunin \| SPINT2 \| PB \| Kop \| HAI2 \| DIAR3 \| HAI-2
Grade	ActiBioPure™, Animal Free, Bioactive, Carrier Free
Product Description	Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Specifications & Purity	ActiBioPure™, Bioactive, Animal Free, Carrier Free, ≥95%(SDS-PAGE)
Bioactivity	Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <4.6 nM, as measured under the described conditions.
Endotoxin Concentration	<0.1 EU/μg
Expression System	HEK293
Species	Human
Amino Acids	1-197 aa
Sequence	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKHHHHHHHHHH
Protein Tag	C-10His
Accession #	O43291
Predicted molecular weight	21 kDa

Product Specifications

Form	Lyophilized
Reconstitution	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.

References

1. Marlor, C W CW and 5 more authors.. (1997) Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains.. The Journal of biological chemistry, (2): [PMID:9115294]
2. Kawaguchi, T T and 6 more authors.. (1997) Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.. The Journal of biological chemistry, (31): [PMID:9346890]
3. Müller-Pillasch, F F and 7 more authors.. (1998) Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer.. Biochimica et biophysica acta, (7): [PMID:9434156]
4. Zhang, Zemin Z and Henzel, William J WJ.. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein science : a publication of the Protein Society, [PMID:15340161]
5. Heinz-Erian, Peter P and 23 more authors.. (2009) Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.. American journal of human genetics, [PMID:19185281]

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Basic Description