Recombinant Human IL-11 Protein, >96% (SDS-PAGE,HPLC), high purity

Features and benefits
  • Expression System: E.coli
  • Accession #: P20809
  • Protein Tag: No tag
  • Bioactivity: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <2ng/mL.
  • Endotoxin Concentration: <0.01 EU/μg
Item Number
rp147371
Grouped product items
SKUSizeAvailabilityPrice Qty
rp147371-10μg
10μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
rp147371-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$499.90
rp147371-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$799.90
rp147371-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,399.90

Animal Free, ≥96% (SDS-PAGE&HPLC), Active, E.coli, No tag, 22-199 aa

Basic Description

Product NameRecombinant Human IL-11 Protein, >96% (SDS-PAGE,HPLC), high purity
SynonymsAdipogenesis inhibitory factor | AGIF | IL-11 | AGIF | Adipogenesis inhibitory factor | AGIFoprelvekin | IL11 | IL-11 | IL-11Oprelvekin | interleukin 11 | interleukin-11 | Oprelvekin
GradeActiBioPure™, Animal Free, Bioactive, Carrier Free, High Performance
Product Description

Function
Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Specifications & PurityAnimal Free, Carrier Free, Bioactive, ActiBioPure™, High performance, ≥96%(SDS-PAGE&HPLC)
Purity>96% (SDS-PAGE,HPLC)
BioactivityMeasured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <2ng/mL.
Endotoxin Concentration<0.01 EU/μg
Expression SystemE.coli
SpeciesHuman
Amino Acids22-199 aa
SequenceGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNL DSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTL EPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIR AAHAILGGLHLTLDWAVRGLLLLKTRL
Protein TagNo tag
Protein LengthFull length protein
Accession #P20809
SourceRecombinant
Predicted molecular weight19.1 kDa

Images

Recombinant Human IL-11 Protein (rp147371)-Protein Bioactivity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <2ng/mL.

Recombinant Human IL-11 Protein (rp147371)-SDS-PAGE
3μg/lane of Recombinant Human IL-11 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a single band at 18.3 kDa.

Product Specifications

FormLyophilized
ReconstitutionThis vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile aqueous buffer to an appropriate concentration. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageFor long term storage, the product should be stored ≤ -20℃. 36 months, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. Upon delivery aliquot. Avo

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ23F0400123Certificate of AnalysisMay 04, 2023 rp147371
ZJ23F0400121Certificate of AnalysisApr 29, 2023 rp147371
ZJ23F0400122Certificate of AnalysisApr 29, 2023 rp147371

Related Documents

References

1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al..  (2004)  Complete sequencing and characterization of 21,243 full-length human cDNAs..  Nat Genet,  36  (1): (40-5).  [PMID:14702039] [10.1021/op500134e]
2. McKinley, D D, Wu, Q Q, Yang-Feng, T T and Yang, Y C YC..  (1992)  Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)..  Genomics,      [PMID:1386338]
3. Kawashima, I I and 7 more authors..  (1991)  Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11..  FEBS letters,    (3):   [PMID:1828438]
4. Paul, S R SR and 9 more authors..  (1990)  Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:2145578]
5. Harmegnies, Dimitri D and 9 more authors..  (2003)  Characterization of a potent human interleukin-11 agonist..  The Biochemical journal,    (1):   [PMID:12919066]
6. Grimwood, Jane J and 97 more authors..  (2004)  The DNA sequence and biology of human chromosome 19..  Nature,    (1):   [PMID:15057824]
7. Putoczki, Tracy L TL, Dobson, Renwick C J RC and Griffin, Michael D W MD..  (2014)  The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6..  Acta crystallographica. Section D, Biological crystallography,      [PMID:25195742]

Solution Calculators