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Recombinant Human IL-2 Protein, ≥95% (SDS-PAGE, SEC-HPLC), high purity(Active)

Features and benefits

Specifications & Purity: ActiBioPure™, Bioactive, GMP, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
Biological Activity: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is typically <2.5ng/mL.
Protein Tag: His

Item Number

rp147476

Grouped product items
SKU	Size	Availability	Price
rp147476-10μg (Trial Size) Apply for free trial size（?） Every year, as a valued customer, you have the exclusive opportunity to explore and enjoy three different trial products of your choice, absolutely free!	10μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$207.90
rp147476-50μg	50μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$447.90
rp147476-100μg	100μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$747.90
rp147476-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$5,517.90

GMP, ≥95% (SDS-PAGE, SEC-HPLC), Active, CHO-K1, His, 21-153 aa

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Accession#:P60568 Gene ID:3558 IL2

Basic Description

Product Name	Recombinant Human IL-2 Protein, ≥95% (SDS-PAGE, SEC-HPLC), high purity
Synonyms	Aldesleukin; IL2; IL-2; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; Proleukin; T cell growth factor; T-cell growth factor; TCGF
Specifications & Purity	ActiBioPure™, Bioactive, GMP, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
Purity	≥95% (SDS-PAGE, SEC-HPLC)
Biological Activity	Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is typically <2.5ng/mL.
Species	Human
Amino Acids	Amino acids
Sequence	APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Protein Tag	His
Protein Length	Full length protein
Accession #	P60568
Source	Recombinant
Predicted molecular weight	15.4 kDa
SDS-PAGE	13.0 kDa, under reducing conditions; 13.0 kDa, under non-reducing conditions.
Grade	ActiBioPure™, Azide Free, Bioactive, Carrier Free, GMP, High performance

Images

Recombinant Human IL-2 Protein (rp147476)-Protein Bioactivity
Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED₅₀ for this effect is typically <2.5ng/mL.

Recombinant Human IL-2 Protein (rp147476) -SDS-PAGE
3μg/lane of Recombinant Human IL-2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a single band at 13.0 kDa.

Product Specifications

Form	Lyophilized
Reconstitution	It is recommended to dissolve the lyophilized rhIL-2 in water for injection or sterilized ultra-pure water with a concentration of not less than 100μg/ml for further dilution to working concentration. Avoid repeated freeze-thaw as much as possible. Rediss
Storage Temp	Store at -20°C
Shipped In	Dry ice
Stability And Storage	Shipped at 4°C. Store at -20°C. Lyophilized with no additives. This product is an active protein and may elicit a biological response in vivo, handle with caution.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0600484	Certificate of Analysis	Jul 03, 2023	rp147476
ZJ23F0600486	Certificate of Analysis	Jul 03, 2023	rp147476
ZJ23F0600485	Certificate of Analysis	Jul 03, 2023	rp147476

References

1. Quéméner A, Maillasson M, Arzel L, Sicard B, Vomiandry R, Mortier E, Dubreuil D, Jacques Y, Lebreton J, Mathé-Allainmat M. (2017) Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.. J Med Chem, 60 (14): (6249-6272). [PMID:28657314]
2. Chen L, Du J, Dai Q, Zhang H, Pang W, Hu J.. (2014) Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.. Eur J Med Chem, 83 (294-306). [PMID:24974349]
3. Żyżyńska-Granica B, Trzaskowski B, Niewieczerzał S, Filipek S, Zegrocka-Stendel O, Dutkiewicz M, Krzeczyński P, Kowalewska M, Koziak K.. (2017) Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.. Eur J Med Chem, 136 (543-547). [PMID:28535470]
4. Laâbi, Y Y and 6 more authors.. (1992) A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.. The EMBO journal, [PMID:1396583]
5. Mott, H R HR and 5 more authors.. (1992) Secondary structure of human interleukin 2 from 3D heteronuclear NMR experiments.. Biochemistry, (25): [PMID:1510960]
6. and Bazan, J F JF.. (1992) Unraveling the structure of IL-2.. Science (New York, N.Y.), (17): [PMID:1631562]
7. Conradt, H S HS and 5 more authors.. (1989) Expression of human interleukin-2 in recombinant baby hamster kidney, Ltk-, and Chinese hamster ovary cells. Structure of O-linked carbohydrate chains and their location within the polypeptide.. The Journal of biological chemistry, (15): [PMID:2793860]
8. Weir, M P MP, Chaplin, M A MA, Wallace, D M DM, Dykes, C W CW and Hobden, A N AN.. (1988) Structure-activity relationships of recombinant human interleukin 2.. Biochemistry, (6): [PMID:3264184]
9. Siebenlist, U U and 7 more authors.. (1986) Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.. Molecular and cellular biology, [PMID:3491296]
10. Brandhuber, B J BJ, Boone, T T, Kenney, W C WC and McKay, D B DB.. (1987) Three-dimensional structure of interleukin-2.. Science (New York, N.Y.), (18): [PMID:3500515]
11. Devos, R R and 7 more authors.. (1983) Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.. Nucleic acids research, (11): [PMID:6306584]
12. Maeda, S S and 9 more authors.. (1983) Cloning of interleukin 2 mRNAs from human tonsils.. Biochemical and biophysical research communications, (30): [PMID:6312994]
13. Fujita, T T, Takaoka, C C, Matsui, H H and Taniguchi, T T.. (1983) Structure of the human interleukin 2 gene.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6324170]
14. Holbrook, N J NJ, Lieber, M M and Crabtree, G R GR.. (1984) DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus.. Nucleic acids research, (25): [PMID:6330695]
15. Robb, R J RJ, Kutny, R M RM, Panico, M M, Morris, H R HR and Chowdhry, V V.. (1984) Amino acid sequence and post-translational modification of human interleukin 2.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6333684]
16. Taniguchi, T T and 6 more authors.. (1983) Structure and expression of a cloned cDNA for human interleukin-2.. Nature, [PMID:6403867]
17. Holbrook, N J NJ and 5 more authors.. (1984) T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6608729]
18. Bamborough, P P, Hedgecock, C J CJ and Richards, W G WG.. (1994) The interleukin-2 and interleukin-4 receptors studied by molecular modelling.. Structure (London, England : 1993), (15): [PMID:7529123]
19. Eizenberg, O O, Faber-Elman, A A, Lotan, M M and Schwartz, M M.. (1995) Interleukin-2 transcripts in human and rodent brains: possible expression by astrocytes.. Journal of neurochemistry, [PMID:7722480]
20. Miyazaki, T T and 9 more authors.. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.. Science (New York, N.Y.), (11): [PMID:7973659]
21. Chernicky, C L CL, Tan, H H, Burfeind, P P, Ilan, J J and Ilan, J J.. (1996) Sequence of interleukin-2 isolated from human placental poly A+ RNA: possible role in maintenance of fetal allograft.. Molecular reproduction and development, [PMID:8824916]
22. Wang, Xinquan X, Rickert, Mathias M and Garcia, K Christopher KC.. (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.. Science (New York, N.Y.), (18): [PMID:16293754]
23. Stauber, Deborah J DJ, Debler, Erik W EW, Horton, Patricia A PA, Smith, Kendall A KA and Wilson, Ian A IA.. (2006) Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.. Proceedings of the National Academy of Sciences of the United States of America, (21): [PMID:16477002]
24. Fiebich, Bernd L BL and 6 more authors.. (2012) Pseudoephedrine inhibits T-cell activation by targeting NF-κB, NFAT and AP-1 signaling pathways.. Immunopharmacology and immunotoxicology, [PMID:21631396]

Recombinant Human IL-2 Protein, ≥95% (SDS-PAGE, SEC-HPLC), high purity(Active)

Basic Description

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Product Specifications

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Certificate of Analysis(COA)

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References