Recombinant Human IL-22 Protein, ＞95% (SDS-PAGE), high purity
ActiBioPure™
Animal Free
Azide Free
Bioactive
Carrier Free
高性能
≥95%(SDS-PAGE)
1mg/ml
Features and benefits
Expression System: HEK293
Accession #: Q9GZX6
Protein Tag: C-His
Bioactivity: Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 160-640 pg/mL.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp147517
Grouped product items
SKU
Size
Availability
Price
Qty
rp147517-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
rp147517-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$489.90
rp147517-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$786.90
rp147517-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Purity >95% SDS-PAGE. Additional sequence information This product is the mature full length protein from aa 34 to 179. Function Cytokine that contributes to the inflammatory response in vivo.
1.Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al.. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res, 13 (10):(2265-70). [PMID:12975309]
2.Xie, M H MH and 8 more authors.. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.. The Journal of biological chemistry, (6):[PMID:10875937]
3.Dumoutier, L L, Van Roost, E E, Colau, D D and Renauld, J C JC.. (2000) Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.. Proceedings of the National Academy of Sciences of the United States of America, (29):[PMID:10954742]
4.Dumoutier, L L, Van Roost, E E, Ameye, G G, Michaux, L L and Renauld, J C JC.. (2000) IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes.. Genes and immunity, [PMID:11197690]
5.Nagem, R A P RA and 5 more authors.. (2002) Crystallization and synchrotron X-ray diffraction studies of human interleukin-22.. Acta crystallographica. Section D, Biological crystallography, [PMID:11856845]
6.Zhang, Zemin Z and Henzel, William J WJ.. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein science : a publication of the Protein Society, [PMID:15340161]
7.Brand, Stephan S and 14 more authors.. (2007) IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.. American journal of physiology. Gastrointestinal and liver physiology, [PMID:17204547]
8.Jones, Brandi C BC, Logsdon, Naomi J NJ and Walter, Mark R MR.. (2008) Structure of IL-22 bound to its high-affinity IL-22R1 chain.. Structure (London, England : 1993), (10):[PMID:18599299]
9.Akil, Hussein H and 12 more authors.. (2015) IL22/IL-22R pathway induces cell survival in human glioblastoma cells.. PloS one, [PMID:25793261]
10.Moniruzzaman, Md M, Wang, Ran R, Jeet, Varinder V, McGuckin, Michael A MA and Hasnain, Sumaira Z SZ.. (2019) Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway.. International journal of molecular sciences, (15):[PMID:31311100]
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