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Recombinant Human IL-34 Protein, ≥95% (SDS-PAGE), high purity

ActiBioPure™
Animal Free
Azide Free
Bioactive
Carrier Free
High performance
≥95%(SDS-PAGE)

Features and benefits

Expression System: CHO
Accession #: Q6ZMJ4
Protein Tag: C-His
Bioactivity: Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED50 for this effect is 2-8 ng/mL.
Endotoxin Concentration: < 1.0 EU/μg

Item Number

rp147566

Grouped product items
SKU	Size	Availability	Price
rp147566-10μg	10μg	In stock	$1,319.90
rp147566-50μg	50μg	In stock	$2,069.90
rp147566-100μg	100μg	In stock	$3,309.90
rp147566-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$21,549.90

Animal Free, ≥95% (SDS-PAGE), Active, CHO, C-His tag, 21-242 aa

View related series

Accession#:Q6ZMJ4 Gene ID:146433 IL34

Basic Description

Product Name	Recombinant Human IL-34 Protein, ≥95% (SDS-PAGE), high purity
Synonyms	C16orf77; IL34; IL-34; interleukin 34; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; Il34; IL34_HUMAN; Interleukin 34; Interleukin-34; Interleukin34; MGC34647
Grade	ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High performance
Product Description	Purity ≥ 95% SDS-PAGE. Function Interleukin-34 (IL-34) is a protein that promotes the proliferation, survival and differentiation of monocytes and macrophages. It also promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. IL-34 plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
Specifications & Purity	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Bioactivity	Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED50 for this effect is 2-8 ng/mL.
Endotoxin Concentration	< 1.0 EU/μg
Expression System	CHO
Species	Human
Amino Acids	21-242 aa
Sequence	NEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVQTLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLPAHHHHHHHHHH
Protein Tag	C-His
Accession #	Q6ZMJ4
Predicted molecular weight	26.7 kDa
SDS-PAGE	37.9 kDa, under reducing conditions; 36.2 kDa, under non-reducing conditions.

Images

Recombinant Human IL-34 Protein (rp147566) - Protein Bioactivity
Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED₅₀ for this effect is 2.0 - 8.0 ng/mL.

Recombinant Human IL-34 Protein (rp147566) - SDS-PAGE
3 μg/lane of Recombinant Human IL-34 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 37.9 kDa under reducing conditions and 36.2 kDa under non-reducing conditions.

Product Specifications

Form	Lyophilized
Reconstitution	It is recommended that sterile water be added to the vial to preparea stock solution of 0.25mg/mL.
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Samples are stable for twelve months from date of receipt at -20℃ to -80℃. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0102330	Certificate of Analysis	Jan 19, 2024	rp147566
ZJ24F0102344	Certificate of Analysis	Jan 19, 2024	rp147566
ZJ24F0102332	Certificate of Analysis	Jan 19, 2024	rp147566

References

1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039]
2. Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D et al.. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.. Science, 320 (5877): (807-11). [PMID:18467591]
3. Martin, Joel J and 121 more authors.. (2004) The sequence and analysis of duplication-rich human chromosome 16.. Nature, (23): [PMID:15616553]
4. Wei, Suwen S and 8 more authors.. (2010) Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.. Journal of leukocyte biology, [PMID:20504948]
5. Eda, Hiroyuki H and 5 more authors.. (2010) Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.. Cytokine, [PMID:20829061]

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