ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High performance
Product Description
Purity ≥ 95% SDS-PAGE. Function Interleukin-34 (IL-34) is a protein that promotes the proliferation, survival and differentiation of monocytes and macrophages. It also promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. IL-34 plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
37.9 kDa, under reducing conditions; 36.2 kDa, under non-reducing conditions.
Images
Recombinant Human IL-34 Protein (rp147566) - Protein Bioactivity Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED₅₀ for this effect is 2.0 - 8.0 ng/mL.
Recombinant Human IL-34 Protein (rp147566) - SDS-PAGE 3 μg/lane of Recombinant Human IL-34 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 37.9 kDa under reducing conditions and 36.2 kDa under non-reducing conditions.
Product Specifications
Form
Lyophilized
Reconstitution
It is recommended that sterile water be added to the vial to preparea stock solution of 0.25mg/mL.
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Samples are stable for twelve months from date of receipt at -20℃ to -80℃. Upon delivery aliquot. Avoid freeze/thaw cycle.
Certificates
Certificate of Analysis(COA)
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1.Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1):(40-5). [PMID:14702039]
2.Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D et al.. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.. Science, 320 (5877):(807-11). [PMID:18467591]
3.Martin, Joel J and 121 more authors.. (2004) The sequence and analysis of duplication-rich human chromosome 16.. Nature, (23):[PMID:15616553]
4.Wei, Suwen S and 8 more authors.. (2010) Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.. Journal of leukocyte biology, [PMID:20504948]
5.Eda, Hiroyuki H and 5 more authors.. (2010) Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.. Cytokine, [PMID:20829061]
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