Recombinant Human Lactoferrin Protein

Features and benefits
  • Expression System: Oryza sativa
  • Accession #: P02788
  • Protein Tag: No tag
  • Endotoxin Concentration: <20 EU/mg
Item Number
rp148153
Grouped product items
SKUSizeAvailabilityPrice Qty
rp148153-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
rp148153-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
rp148153-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$859.90

GMP, ≥95% (SDS-PAGE), Oryza sativa, No tag, 1-711 aa

Basic Description

Product NameRecombinant Human Lactoferrin Protein
SynonymsEC 3.4.21.- | Growth-inhibiting protein 12 | Lactoferrin | Talalactoferrin | Growth inhibiting protein 12 | HLF2 | Kaliocin 1 | Lactoferrin | Lactoferroxin-C | Lactotransferrin | LF | LTF | Neutrophil lactoferrin | Talalactoferrin | TRFL_HUMAN | HEL110 |
GradeActiBioPure™, Animal Free, Carrier Free, GMP
Specifications & PurityActiBioPure™, GMP, Animal Free, Carrier Free, ≥95%(SDS-PAGE)
Biochemical and Physiological MechanismsTransferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactofer
Endotoxin Concentration<20 EU/mg
Expression SystemOryza sativa
SpeciesHuman
Amino Acids1-711 aa
Protein TagNo tag
Accession #P02788
Predicted molecular weight80 kDa

Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile PBS to a concentration of 10 mg/ml. After dissolution, sterile OsrhLF can be stored at 4 ℃ for 1 month.
Storage TempStore at 2-8°C
Shipped InWet ice
Stability And StorageStore at 2-8℃ for 24 months. Upon delivery aliquot.
CAS146897-68-9

Certificates

Certificate of Analysis(COA)

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Related Documents

Citations of This Product

1. Binbin Hu, Huaqiang Fang, Zhixin Huang, Wenjing Huang, Li Huang, Huijie Liu, Fanzhen Lv, Wei Huang, Xiaolei Wang.  (2023)  An upconversion nanoplatform based multi-effective theatment for Parkinson’s disease.  CHEMICAL ENGINEERING JOURNAL,  465  (142959).  [PMID:] [10.1016/j.cej.2023.142959]

References

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18. Day, C L CL, Anderson, B F BF, Tweedie, J W JW and Baker, E N EN..  (1993)  Structure of the recombinant N-terminal lobe of human lactoferrin at 2.0 A resolution..  Journal of molecular biology,    (20):   [PMID:8371268]
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21. Baker, H M HM and 5 more authors..  (1996)  Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin..  Biochemistry,    (16):   [PMID:8703903]
22. Faber, H R HR, Baker, C J CJ, Day, C L CL, Tweedie, J W JW and Baker, E N EN..  (1996)  Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants..  Biochemistry,    (19):   [PMID:8931543]
23. Nicholson, H H and 5 more authors..  (1997)  Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant..  Biochemistry,    (14):   [PMID:9003186]
24. Siebert, P D PD and Huang, B C BC..  (1997)  Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines..  Proceedings of the National Academy of Sciences of the United States of America,    (18):   [PMID:9122171]
25. van Berkel, P H PH and 5 more authors..  (1997)  N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA..  The Biochemical journal,    (15):   [PMID:9359845]
26. Klintworth, G K GK and 21 more authors..  (1998)  Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene..  Molecular vision,    (31):   [PMID:9873069]
27. Sun, X L XL, Baker, H M HM, Shewry, S C SC, Jameson, G B GB and Baker, E N EN..  (1999)  Structure of recombinant human lactoferrin expressed in Aspergillus awamori..  Acta crystallographica. Section D, Biological crystallography,      [PMID:10089347]
28. Jameson, G B GB, Anderson, B F BF, Norris, G E GE, Thomas, D H DH and Baker, E N EN..  (1998)  Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change..  Acta crystallographica. Section D, Biological crystallography,    (1):   [PMID:10089508]
29. Abrink, M M, Larsson, E E, Gobl, A A and Hellman, L L..  (2000)  Expression of lactoferrin in the kidney: implications for innate immunity and iron metabolism..  Kidney international,      [PMID:10792619]
30. Peterson, N A NA, Anderson, B F BF, Jameson, G B GB, Tweedie, J W JW and Baker, E N EN..  (2000)  Crystal structure and iron-binding properties of the R210K mutant of the N-lobe of human lactoferrin: implications for iron release from transferrins..  Biochemistry,    (6):   [PMID:10828980]
31. Lupetti, A A and 5 more authors..  (2000)  Candidacidal activities of human lactoferrin peptides derived from the N terminus..  Antimicrobial agents and chemotherapy,      [PMID:11083624]
32. Baker, H M HM, Baker, C J CJ, Smith, C A CA and Baker, E N EN..  (2000)  Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin..  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,      [PMID:11128996]
33. Nibbering, P H PH and 6 more authors..  (2001)  Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria..  Infection and immunity,      [PMID:11179314]
34. Cheng, H H, Chen, X Z XZ and Huan, L D LD..  (2001)  [cDNA cloning and sequence analysis of human lactoferrin]..  Sheng wu gong cheng xue bao = Chinese journal of biotechnology,      [PMID:11702692]
35. Jameson, Geoffrey B GB and 5 more authors..  (2002)  Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form..  Acta crystallographica. Section D, Biological crystallography,      [PMID:12037297]
36. Singh, Pradeep K PK, Parsek, Matthew R MR, Greenberg, E Peter EP and Welsh, Michael J MJ..  (2002)  A component of innate immunity prevents bacterial biofilm development..  Nature,    (30):   [PMID:12037568]
37. Peterson, Neil A NA and 5 more authors..  (2002)  "Dilysine trigger" in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin..  Biochemistry,    (3):   [PMID:12450380]
38. Hendrixson, D R DR and 7 more authors..  (2003)  Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites..  Molecular microbiology,      [PMID:12535064]
39. Liu, Dianxin D, Wang, Xin X, Zhang, Zhiping Z and Teng, Christina T CT..  (2003)  An intronic alternative promoter of the human lactoferrin gene is activated by Ets..  Biochemical and biophysical research communications,    (7):   [PMID:12565886]
40. Viejo-Díaz, M M, Andrés, M T MT, Pérez-Gil, J J, Sánchez, M M and Fierro, J F JF..  (2003)  Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane..  Biochemistry. Biokhimiia,      [PMID:12693969]
41. Velliyagounder, Kabilan K and 6 more authors..  (2003)  One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis..  Infection and immunity,      [PMID:14573629]
42. Cornish, Jillian J and 17 more authors..  (2004)  Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo..  Endocrinology,      [PMID:15166119]
43. Breton, Mathilde M and 8 more authors..  (2004)  Expression of delta-lactoferrin induces cell cycle arrest..  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,      [PMID:15222485]
44. Smith, C A CA, Anderson, B F BF, Baker, H M HM and Baker, E N EN..  (1994)  Structure of copper- and oxalate-substituted human lactoferrin at 2.0 A resolution..  Acta crystallographica. Section D, Biological crystallography,    (1):   [PMID:15299444]
45. Haridas, M M, Anderson, B F BF and Baker, E N EN..  (1995)  Structure of human diferric lactoferrin refined at 2.2 A resolution..  Acta crystallographica. Section D, Biological crystallography,    (1):   [PMID:15299793]
46. Japelj, Bostjan B, Pristovsek, Primoz P, Majerle, Andreja A and Jerala, Roman R..  (2005)  Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide..  The Journal of biological chemistry,    (29):   [PMID:15687491]
47. Hunter, Howard N HN, Demcoe, A Ross AR, Jenssen, Håvard H, Gutteberg, Tore J TJ and Vogel, Hans J HJ..  (2005)  Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent..  Antimicrobial agents and chemotherapy,      [PMID:16048952]
48. Thomassen, Ellen A J EA, van Veen, Harrie A HA, van Berkel, Patrick H C PH, Nuijens, Jan H JH and Abrahams, Jan Pieter JP..  (2005)  The protein structure of recombinant human lactoferrin produced in the milk of transgenic cows closely matches the structure of human milk-derived lactoferrin..  Transgenic research,      [PMID:16201406]
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50. Kim, Chan Woo CW, Son, Kyung-No KN, Choi, Sang-Yun SY and Kim, Jiyoung J..  (2006)  Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated endothelial cell proliferation and migration..  FEBS letters,    (7):   [PMID:16842782]
51. Johansson, Cecilia C and 8 more authors..  (2007)  Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells..  Journal of virology,      [PMID:17079302]
52. Japelj, Bostjan B and 11 more authors..  (2007)  The acyl group as the central element of the structural organization of antimicrobial lipopeptide..  Journal of the American Chemical Society,    (7):   [PMID:17263370]
53. Mistry, Nitesh N and 5 more authors..  (2007)  The anti-papillomavirus activity of human and bovine lactoferricin..  Antiviral research,      [PMID:17481742]
54. Senkovich, Olga O and 6 more authors..  (2007)  Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism..  Journal of molecular biology,    (20):   [PMID:17543335]
55. Wang, Zengjun Z, Widgren, Esther E EE, Richardson, Richard T RT and O'Rand, Michael G MG..  (2007)  Characterization of an eppin protein complex from human semen and spermatozoa..  Biology of reproduction,      [PMID:17567961]
56. Bournazou, Irini I and 7 more authors..  (2009)  Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin..  The Journal of clinical investigation,      [PMID:19033648]
57. Ando, Ken K and 12 more authors..  (2010)  Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling..  The FEBS journal,      [PMID:20345905]
58. Hardivillé, Stéphan S, Hoedt, Esthelle E, Mariller, Christophe C, Benaïssa, Monique M and Pierce, Annick A..  (2010)  O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin..  The Journal of biological chemistry,    (18):   [PMID:20404350]
59. Mariller, Christophe C and 5 more authors..  (2012)  Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor..  Biochemistry and cell biology = Biochimie et biologie cellulaire,      [PMID:22320386]
60. Videm, Vibeke V, Dahl, Hildegunn H, Wålberg, Lise Eid LE and Wiseth, Rune R..  (2012)  Functional polymorphisms in the LTF gene and risk of coronary artery stenosis..  Human immunology,      [PMID:22406253]
61. Kumar, Janesh J and 12 more authors..  (2003)  Crystal structure of human seminal diferric lactoferrin at 3.4 Angstrom resolution..  Indian journal of biochemistry & biophysics,      [PMID:22900286]
62. Binbin Hu, Huaqiang Fang, Zhixin Huang, Wenjing Huang, Li Huang, Huijie Liu, Fanzhen Lv, Wei Huang, Xiaolei Wang.  (2023)  An upconversion nanoplatform based multi-effective theatment for Parkinson’s disease.  CHEMICAL ENGINEERING JOURNAL,  465  (142959).  [PMID:] [10.1016/j.cej.2023.142959]

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