Purity >95% SDS-PAGE. Additional sequence information Extracellular domain fused with Fc tag at the C-terminus.
Function Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Recombinant Human LTBR Protein (rp148424) - Protein Bioactivity Immobilized Recombinant Human LIGHT at 1.0 μg/mL can bind Recombinant Human LTBR Protein (rp148424) with a linear range of 15.0 - 55.0 ng/mL.
Recombinant Human LTBR Protein (rp148424) - SDS-PAGE 3 μg/lane of Recombinant Human LTBR Protein was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing a band at 61.5 kDa under reducing condition.
Product Specifications
Form
Lyophilized
Reconstitution
Reconstitute in water to a concentration of 0.1-0.5 mg/ml.
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20~-80℃ for more than 1 year.
Certificates
Certificate of Analysis(COA)
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1.Crowe, P D PD and 9 more authors.. (1994) A lymphotoxin-beta-specific receptor.. Science (New York, N.Y.), (29):[PMID:8171323]
2.Baens, M M, Chaffanet, M M, Cassiman, J J JJ, van den Berghe, H H and Marynen, P P.. (1993) Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.. Genomics, [PMID:8486360]
3.Nakano, H H and 6 more authors.. (1996) TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.. The Journal of biological chemistry, (21):[PMID:8663299]
4.Matsumoto, M M and 10 more authors.. (1997) Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.. Journal of virology, [PMID:8995654]
5.Mizushima, S S and 8 more authors.. (1998) Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).. Gene, (30):[PMID:9511754]
6.Krajewska, M M and 11 more authors.. (1998) TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.. The American journal of pathology, [PMID:9626059]
7.Wu, M Y MY, Wang, P Y PY, Han, S H SH and Hsieh, S L SL.. (1999) The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.. The Journal of biological chemistry, (23):[PMID:10207006]
8.Rooney, I A IA and 8 more authors.. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.. The Journal of biological chemistry, (12):[PMID:10799510]
9.Scherer, Steven E SE and 216 more authors.. (2006) The finished DNA sequence of human chromosome 12.. Nature, (16):[PMID:16541075]
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