Bioactivity: Recombinant Human Nectin-2/CD112 Protein is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2, thus a binding ELISA assay was conducted to dete
Endotoxin Concentration: <1.0 EU/μg
Item Number
rp149154
Grouped product items
SKU
Size
Availability
Price
Qty
rp149154-10μg
10μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
rp149154-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$389.90
rp149154-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$619.90
rp149154-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Recombinant Human Nectin-2/CD112 Protein is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2, thus a binding ELISA assay was conducted to dete
46.6 kDa, under reducing conditions; 40.0 kDa, under non-reducing conditions.
Images
Recombinant Human Nectin-2/CD112 Protein (rp149154) - Protein Bioactivity Recombinant Human Nectin-2/CD112 Protein (rp149154) is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2/CD112, thus a binding ELISA assay was conducted to detect the interaction of recombinant human Nectin-2/CD112 and recombinant DNAM-1/CD226 hFc.
Recombinant Human Nectin-2/CD112 Protein (rp149154) - SDS-PAGE 2.5 μg/lane of Recombinant Human Nectin-2/CD112 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 46.6 kDa under reducing conditions and 40.0 kDa under non-reducing conditions.
Product Specifications
Form
Lyophilized
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25mg/mL.
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Samples are stable for up to twelve months from date of receipt at -70 ℃. Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Certificates
Certificate of Analysis(COA)
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1.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H et al.. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.. Nat Immunol, 10 (1):(48-57). [PMID:19011627][10.1021/op500134e]
2.Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. (2016) Identification of CD112R as a novel checkpoint for human T cells.. J Exp Med, 213 (2):(167-76). [PMID:26755705][10.1021/op500134e]
3.Eberlé, F F, Dubreuil, P P, Mattei, M G MG, Devilard, E E and Lopez, M M.. (1995) The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.. Gene, (4):[PMID:7622062]
4.Warner, M S MS and 8 more authors.. (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.. Virology, (20):[PMID:9657005]
5.Freitas, E M EM and 7 more authors.. (1998) Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.. DNA sequence : the journal of DNA sequencing and mapping, [PMID:10520737]
6.Martinez, W M WM and Spear, P G PG.. (2001) Structural features of nectin-2 (HveB) required for herpes simplex virus entry.. Journal of virology, [PMID:11602758]
7.Pende, Daniela D and 13 more authors.. (2005) PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.. Molecular immunology, [PMID:15607800]
8.Samanta, Dibyendu D and 5 more authors.. (2012) Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.. Proceedings of the National Academy of Sciences of the United States of America, (11):[PMID:22927415]
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