Recombinant Human Noggin Protein, ≥95% (SDS-PAGE), high purity

Features and benefits
  • Expression System: HEK293
  • Accession #: Q13253
  • Protein Tag: C-His
  • Bioactivity: Immobilized Human BMP2 at 1 μg/mL (100 μL/well) can bind Noggin with a linear range of 2-57 ng/mL.
  • Endotoxin Concentration: <0.1 EU/μg
Item Number
rp149360
Grouped product items
SKUSizeAvailabilityPrice Qty
rp149360-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
rp149360-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
rp149360-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$469.90
rp149360-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,399.90

Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 28-232 aa

Basic Description

Product NameRecombinant Human Noggin Protein, ≥95% (SDS-PAGE), high purity
SynonymsNOG | Noggin | SYM1 | symphalangism 1 (proximal) | synostoses (multiple) syndrome 1 | SYNS1 | SYNS1A
GradeActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free
Product Description

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.

Specifications & PurityActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
Purity≥95% (SDS-PAGE)
BioactivityImmobilized Human BMP2 at 1 μg/mL (100 μL/well) can bind Noggin with a linear range of 2-57 ng/mL.
Endotoxin Concentration<0.1 EU/μg
Expression SystemHEK293
SpeciesHuman
Amino Acids28-232 aa
SequenceQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSCHHHHHH
Protein TagC-His
Accession #Q13253
Predicted molecular weight24 kDa
SDS-PAGE35-38 kDa under reducing conditions.

Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Valenzuela, D M DM and 9 more authors..  (1995)  Identification of mammalian noggin and its expression in the adult nervous system..  The Journal of neuroscience : the official journal of the Society for Neuroscience,      [PMID:7666191]
2. Gong, Y Y and 17 more authors..  (1999)  Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis..  Nature genetics,      [PMID:10080184]
3. Dixon, M E ME, Armstrong, P P, Stevens, D B DB and Bamshad, M M..  ()  Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism..  Genetics in medicine : official journal of the American College of Medical Genetics,      [PMID:11545688]
4. Takahashi, T T and 7 more authors..  (2001)  Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome..  Clinical genetics,      [PMID:11846737]
5. Mangino, M M, Flex, E E, Digilio, M C MC, Giannotti, A A and Dallapiccola, B B..  (2002)  Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism..  Human mutation,      [PMID:11857750]
6. Brown, David J DJ and 8 more authors..  (2002)  Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin..  American journal of human genetics,      [PMID:12089654]
7. Groppe, Jay J and 9 more authors..  (2002)  Structural basis of BMP signalling inhibition by the cystine knot protein Noggin..  Nature,    (12):   [PMID:12478285]
8. van den Ende, J J JJ and 6 more authors..  (2005)  The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene..  Clinical dysmorphology,      [PMID:15770128]
9. Lehmann, K K and 12 more authors..  (2007)  A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN..  American journal of human genetics,      [PMID:17668388]
10. Rudnik-Schöneborn, Sabine S and 6 more authors..  (2010)  Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation..  American journal of medical genetics. Part A,      [PMID:20503332]
11. Schwaerzer, Gerburg K GK and 7 more authors..  (2012)  New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance..  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,      [PMID:21976273]
12. Degenkolbe, Elisa E and 13 more authors..  (2013)  A GDF5 point mutation strikes twice--causing BDA1 and SYNS2..  PLoS genetics,      [PMID:24098149]
13. Wang, Jian J and 16 more authors..  (2016)  A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal..  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,      [PMID:26643732]
14. Yang, Yongjia Y and 8 more authors..  (2019)  SMAD6 is frequently mutated in nonsyndromic radioulnar synostosis..  Genetics in medicine : official journal of the American College of Medical Genetics,    (29):   [PMID:31138930]

Solution Calculators