Recombinant Human p21 Protein, >90% (SDS-PAGE), high purity

Features and benefits
  • Expression System: E. coli
  • Protein Tag: N-His
  • Endotoxin Concentration: <1.0 EU/μg
Item Number
rp156666
Grouped product items
SKUSizeAvailabilityPrice Qty
rp156666-10μg (Trial Size)
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10μg
In stock
$99.90
rp156666-100μg
100μg
Available within 8-12 weeks(?)
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$399.90
rp156666-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90

Carrier Free, >90% (SDS-PAGE), E. coli, N-His tag, 1-164 aa

Basic Description

Product NameRecombinant Human p21 Protein, >90% (SDS-PAGE), high purity
SynonymsCAP20 | CDK-interacting protein 1 | CDKI | CDKN1 | Cdkn1a | CDN1A_HUMAN | CIP1 | Cyclin Dependent Kinase Inhibitor 1A | Cyclin-dependent kinase inhibitor 1 | Cyclin-dependent kinase inhibitor 1A (P21) | DNA Synthesis Inhibitor | Cyclin-dependent kinase in
GradeAzide Free, Carrier Free
Product Description

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description:
p21CIP1, also called CIP1 (CDK-interacting protein 1) and CDKN1A, is a 21 kDa Cyclin/Cyclin-dependent kinase (Cdk) inhibitor that blocks cell cycle progression from G1 to S phase in the cell cycle. Because p21 is a transcriptional target of the p53 tumor suppressor, p21 expression increases in cells that contain stabilized p53 due to genotoxic stress exposure. May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Specifications & PurityCarrier Free, Azide Free, ≥90%(SDS-PAGE)
Purity>90% (SDS-PAGE)
Endotoxin Concentration<1.0 EU/μg
Expression SystemE. coli
Amino Acids1-164 aa
SequenceMGHHHHHHMSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
Protein TagN-His
Predicted molecular weight18.1 kDa
SDS-PAGE18.4 kDa, under reducing conditions

Images

Recombinant Human p21 Protein (rp156666) - SDS-PAGE
3 μg/lane of Recombinant Human p21 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 18.4 kDa under reducing conditions.

Product Specifications

FormLyophilized
ReconstitutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20°C stable up to 1 year. Avoid freeze / thaw cycle.

Certificates

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4 results found

Lot NumberCertificate TypeDateItem
ZJ24F0303251Certificate of AnalysisMar 18, 2024 rp156666
ZJ24F0303250Certificate of AnalysisMar 18, 2024 rp156666
ZJ24F0303252Certificate of AnalysisMar 18, 2024 rp156666
ZJ24R0300324Certificate of AnalysisMar 08, 2024 rp156666

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