Bioactivity: Measured by its binding ability in a functional ELISA. When peptidoglycan is coated at 1 µg/mL (100 µL/well), the concentration of Recombinant Human PGLYRP1/PGRP-S that produces 50% optimal binding response is 0.75-4.5 ng/mL.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp150150
Grouped product items
SKU
Size
Availability
Price
Qty
rp150150-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
rp150150-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$469.90
rp150150-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$799.90
rp150150-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Function Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Measured by its binding ability in a functional ELISA. When peptidoglycan is coated at 1 µg/mL (100 µL/well), the concentration of Recombinant Human PGLYRP1/PGRP-S that produces 50% optimal binding response is 0.75-4.5 ng/mL.
1.Denis V Yashin,Olga K Ivanova,Natalia V Soshnikova,Anton A Sheludchenkov,Elena A Romanova,Elena A Dukhanina,Alexander G Tonevitsky,Nikolai V Gnuchev,Alexander G Gabibov,Georgii P Georgiev,Lidia P Sashchenko. (2015-07-18) Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.. The Journal of biological chemistry, 290 ((35)):(21724-21731). [PMID:26183779]
2.Kang, D D, Liu, G G, Lundström, A A, Gelius, E E and Steiner, H H.. (1998) A peptidoglycan recognition protein in innate immunity conserved from insects to humans.. Proceedings of the National Academy of Sciences of the United States of America, (18):[PMID:9707603]
3.Liu, C C, Xu, Z Z, Gupta, D D and Dziarski, R R.. (2001) Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.. The Journal of biological chemistry, (14):[PMID:11461926]
4.Guan, Rongjin R, Wang, Qian Q, Sundberg, Eric J EJ and Mariuzza, Roy A RA.. (2005) Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.. Journal of molecular biology, (8):[PMID:15769462]
5.Lu, Xiaofeng X and 6 more authors.. (2006) Peptidoglycan recognition proteins are a new class of human bactericidal proteins.. The Journal of biological chemistry, (3):[PMID:16354652]
6.Yashin, Denis V DV and 10 more authors.. (2011) The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.. The Journal of biological chemistry, (25):[PMID:21247889]
7.Read, Christine B CB and 14 more authors.. (2015) Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.. Journal of immunology (Baltimore, Md. : 1950), (15):[PMID:25595774]
8.Dukhanina, E A EA and 7 more authors.. (2015) A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.. Cell cycle (Georgetown, Tex.), [PMID:26654597]
9.Sharapova, Tatiana N TN and 5 more authors.. (2017) Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.. Journal of innate immunity, [PMID:28977785]
10.Sharapova, Tatiana N TN and 5 more authors.. (2017) Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.. IUBMB life, [PMID:29083508]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
