Recombinant Human Siglec-9 Protein, ≥95% (SDS-PAGE), high purity

Features and benefits

Expression System: HEK293
Protein Tag: C-hFc & His
Bioactivity: Measured by the ability of the immobilized protein to support the adhesion of human red blood cells.The ED50 for this effect is 10.0-100 ng/mL.
Endotoxin Concentration: ＜0.1 EU/μg

Item Number

rp168101

Grouped product items
SKU	Size	Availability	Price
rp168101-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
rp168101-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$349.90
rp168101-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$599.90
rp168101-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,999.90

Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-hFc&His tag, 18-348 aa

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Basic Description

Product Name	Recombinant Human Siglec-9 Protein, ≥95% (SDS-PAGE), high purity
Synonyms	Sialic Acid Binding Ig-like Lectin 9 \| CD329 \| CDw329 \| FOAP-9 \| OBBP-Like \| Protein FOAP-9 \| sialic acid-binding Ig-like lectin 9 \| Siglec9 \| Siglec-9
Grade	ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description	Purity ≥95% SDS-PAGE. Endotoxin level <0.1 EU/µg Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Specifications & Purity	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Bioactivity	Measured by the ability of the immobilized protein to support the adhesion of human red blood cells.The ED50 for this effect is 10.0-100 ng/mL.
Endotoxin Concentration	＜0.1 EU/μg
Expression System	HEK293
Amino Acids	18-348 aa
Sequence	QTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVC
Protein Tag	C-hFc & His
Predicted molecular weight	64 kDa
SDS-PAGE	90-100 kDa under reducing conditions.

Product Specifications

Form	Lyophilized
Reconstitution	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0607363	Certificate of Analysis	Jun 28, 2024	rp168101
ZJ24F0607362	Certificate of Analysis	Jun 28, 2024	rp168101
ZJ24F0607361	Certificate of Analysis	Jun 28, 2024	rp168101

References

1. Prescher H, Frank M, Gütgemann S, Kuhfeldt E, Schweizer A, Nitschke L, Watzl C, Brossmer R.. (2017) Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion.. J Med Chem, 60 (3): (941-956). [PMID:28103033]
2. Angata, T T and Varki, A A.. (2000) Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.. The Journal of biological chemistry, (21): [PMID:10801860]
3. Zhang, J Q JQ, Nicoll, G G, Jones, C C and Crocker, P R PR.. (2000) Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.. The Journal of biological chemistry, (21): [PMID:10801862]
4. Foussias, G G, Yousef, G M GM and Diamandis, E P EP.. (2000) Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).. Genomics, (15): [PMID:10903842]

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Basic Description