| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| rp175925-10μg | 10μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $99.90 | |
| rp175925-50μg | 50μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
| rp175925-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| rp175925-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,599.90 |
Carrier free, >90% SDS-PAGE, E.coli, N-His tag, 1-142 aa
| Product Name | Recombinant Human Survivin Protein |
|---|---|
| Synonyms | API4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP Repeat-Containing Protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha; Survivin; SVV; TIAP |
| Grade | Azide Free, Carrier Free |
| Product Description | Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Survivin acts as an important regulator of the localization of this complex. It may counteract a default induction of apoptosis in G2/M phase. |
| Specifications & Purity | Carrier Free, Azide Free, ≥90%(SDS-PAGE) |
| Expression System | E. coli |
| Amino Acids | 1-142 aa |
| Sequence | MHHHHHHGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
| Protein Tag | N-His |
| Predicted molecular weight | 17.2 kDa |
| SDS-PAGE | 15.6 kDa, under reducing conditions |
Recombinant Human Survivin Protein (rp175925) - SDS-PAGE
3 μg/lane of Recombinant Human Survivin Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 15.6 kDa under reducing conditions.
| Form | Lyophilized |
|---|---|
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -20°C stable up to 1 year. Avoid freeze / thaw cycle. |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0606718 | Certificate of Analysis | Jun 14, 2024 | rp175925 |
| ZJ24F0606717 | Certificate of Analysis | Jun 14, 2024 | rp175925 |
| 1. S K Knauer,U-R Heinrich,C Bier,N Habtemichael,D Docter,K Helling,W J Mann,R H Stauber. (2011-03-03) An otoprotective role for the apoptosis inhibitor protein survivin.. Cell death & disease, 1 (e51-e51). [PMID:21364656] |
| 2. Somsundaram N Chettiar, James V Cooley, In-Hee Park, Deepak Bhasin, Arnab Chakravarti, Pui-Kai Li, Chenglong Li, Naduparambil Korah Jacob,. (2013-08-24) Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle.. Bioorganic & medicinal chemistry letters, 23 ((19)): ( 5429-5433 ). [PMID:23968825] |
| 3. Abadi AH, Abouel-Ella DA, Lehmann J, Tinsley HN, Gary BD, Piazza GA, Abdel-Fattah MA.. (2010) Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.. Eur J Med Chem, 45 (1): (90-97). [PMID:19836860] |
| 4. Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC, Liao WS, McMurray JS.. (2011) Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.. J Med Chem, 54 (10): (3549-3563). [PMID:21486047] |
| 5. Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W.. (2018) Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.. Eur J Med Chem, 149 (211-224). [PMID:29501942] |
| 6. Ambrosini, G G, Adida, C C and Altieri, D C DC.. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.. Nature medicine, [PMID:9256286] |
| 7. Li, F F and 6 more authors.. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin.. Nature, (10): [PMID:9859993] |
| 8. Mahotka, C C, Wenzel, M M, Springer, E E, Gabbert, H E HE and Gerharz, C D CD.. (1999) Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.. Cancer research, (15): [PMID:10626797] |
| 9. Verdecia, M A MA and 5 more authors.. (2000) Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.. Nature structural biology, [PMID:10876248] |
| 10. Chantalat, L L and 5 more authors.. (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.. Molecular cell, [PMID:10949039] |
| 11. O'Connor, D S DS and 8 more authors.. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.. Proceedings of the National Academy of Sciences of the United States of America, (21): [PMID:11069302] |
| 12. Uren, A G AG and 6 more authors.. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.. Current biology : CB, (2): [PMID:11084331] |
| 13. Marusawa, Hiroyuki H and 6 more authors.. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression.. The EMBO journal, (2): [PMID:12773388] |
| 14. Wheatley, Sally P SP, Henzing, Alexander J AJ, Dodson, Helen H, Khaled, Walid W and Earnshaw, William C WC.. (2004) Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.. The Journal of biological chemistry, (13): [PMID:14610074] |
| 15. Badran, Adel A and 6 more authors.. (2004) Identification of a novel splice variant of the human anti-apoptopsis gene survivin.. Biochemical and biophysical research communications, (13): [PMID:14741722] |
| 16. Gassmann, Reto R and 8 more authors.. (2004) Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.. The Journal of cell biology, (19): [PMID:15249581] |
| 17. Samuel, Temesgen T and 5 more authors.. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.. Cancer research, (1): [PMID:15665297] |
| 18. Vader, Gerben G, Kauw, Jos J W JJ, Medema, René H RH and Lens, Susanne M A SM.. (2006) Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.. EMBO reports, [PMID:16239925] |
| 19. Noton, Elizabeth A EA and 6 more authors.. (2006) Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.. The Journal of biological chemistry, (13): [PMID:16291752] |
| 20. Vong, Queenie P QP, Cao, Kan K, Li, Hoi Y HY, Iglesias, Pablo A PA and Zheng, Yixian Y.. (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin.. Science (New York, N.Y.), (2): [PMID:16322459] |
| 21. Zheng, Wenyun W and 5 more authors.. (2005) Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.. DNA sequence : the journal of DNA sequencing and mapping, [PMID:16329164] |
| 22. Wheatley, Sally P SP and McNeish, Iain A IA.. (2005) Survivin: a protein with dual roles in mitosis and apoptosis.. International review of cytology, [PMID:16344111] |
| 23. Chang, Junn-Liang JL and 7 more authors.. (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer.. Experimental cell research, (15): [PMID:16427043] |
| 24. Lens, Susanne M A SM and 5 more authors.. (2006) Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.. Molecular biology of the cell, [PMID:16436504] |
| 25. Cao, Lihuan L and 7 more authors.. (2006) Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.. Biochemical and biophysical research communications, (28): [PMID:16762323] |
| 26. Faitar, Silviu L SL, Sossey-Alaoui, Khalid K, Ranalli, Tamara A TA and Cowell, John K JK.. (2006) EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.. Experimental cell research, (15): [PMID:16764853] |
| 27. Jeyaprakash, A Arockia AA and 5 more authors.. (2007) Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.. Cell, (19): [PMID:17956729] |
| 28. Gagarina, Viktoria V, Carlberg, Alyssa L AL, Pereira-Mouries, Lucilia L and Hall, David J DJ.. (2008) Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.. The Journal of biological chemistry, (4): [PMID:17993464] |
| 29. Pohl, Christian C and Jentsch, Stefan S.. (2008) Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.. Cell, (7): [PMID:18329369] |
| 30. Xia, Fang F, Canovas, Pedro M PM, Guadagno, Thomas M TM and Altieri, Dario C DC.. (2008) A survivin-ran complex regulates spindle formation in tumor cells.. Molecular and cellular biology, [PMID:18591255] |
| 31. Bourhis, Eric E, Lingel, Andreas A, Phung, Qui Q, Fairbrother, Wayne J WJ and Cochran, Andrea G AG.. (2009) Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.. Biochemistry, (28): [PMID:19530738] |
| 32. Habtemichael, Negusse N and 10 more authors.. (2010) Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.. Molecular and cellular neurosciences, [PMID:20627126] |
| 33. Yamagishi, Yuya Y, Honda, Takashi T, Tanno, Yuji Y and Watanabe, Yoshinori Y.. (2010) Two histone marks establish the inner centromere and chromosome bi-orientation.. Science (New York, N.Y.), (8): [PMID:20929775] |
| 34. Platica, Micsunica M and 5 more authors.. (2011) PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.. International journal of oncology, [PMID:21225229] |
| 35. Barrett, Rachel M A RM, Colnaghi, Rita R and Wheatley, Sally P SP.. (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.. Cell cycle (Georgetown, Tex.), (1): [PMID:21252625] |
| 36. Pavlyukov, Marat S MS and 5 more authors.. (2011) Survivin monomer plays an essential role in apoptosis regulation.. The Journal of biological chemistry, (1): [PMID:21536684] |
| 37. Li, Zhijun Z and 6 more authors.. (2014) CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.. Molecular cell, (5): [PMID:24793696] |
| 38. Park, Mi Hee MH, Kim, Soo Yeon SY, Kim, Young Ju YJ and Chung, Young-Ho YH.. (2014) ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.. Biochemical and biophysical research communications, (18): [PMID:24866247] |
| 39. Liu, Yuan Y and 8 more authors.. (2015) The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.. The Journal of biological chemistry, (8): [PMID:25778398] |
| 40. Sasai, Kaori K, Katayama, Hiroshi H, Hawke, David H DH and Sen, Subrata S.. (2016) Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.. PloS one, [PMID:27332895] |
| 41. Dheekollu, Jayaraju and 7 more authors.. (2017) Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.. Oncotarget, (31): [PMID:28077791] |
| 42. Kamran, M M and 8 more authors.. (2017) Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.. Oncogenesis, (20): [PMID:28218735] |
