Bioactivity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
Endotoxin Concentration: <0.01 EU/μg
Item Number
rp152075
Grouped product items
SKU
Size
Availability
Price
Qty
rp152075-10μg
10μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$99.90
rp152075-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$369.90
rp152075-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$599.90
rp152075-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Recombinant Human TARC/CCL17 Protein, >97% (SDS-PAGE and HPLC), high purity
Synonyms
ABCD-2; CC chemokine TARC; C-C motif chemokine 17; CCL17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TAR
Grade
ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description
Purity > 97% by SDS-PAGE and HPLC analyses.
Function Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
Recombinant Human TARC/CCL17(rp152075)-Protein Bioactivity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/mL.
Recombinant Human TARC/CCL17 Protein (rp152075)-SDS-PAGE Recombinant Human TARC/CCL17 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 8.1 kDa under reducing conditionsand and 8.0-13.0kDa under non-reducing conditions.
Product Specifications
Form
Lyophilized
Reconstitution
Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Stability And Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst
Certificates
Certificate of Analysis(COA)
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1.Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A et al.. (1998) Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.. Eur J Immunol, 28 (2):(582-8). [PMID:9521068]
2.Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D et al.. (2018) Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.. J Med Chem, 61 (17):(7671-7686). [PMID:30106292]
3.Imai, T T and 5 more authors.. (1996) Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.. The Journal of biological chemistry, (30):[PMID:8702936]
4.Imai, T T and 5 more authors.. (1997) The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.. The Journal of biological chemistry, (6):[PMID:9169480]
5.Loftus, B J BJ and 18 more authors.. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.. Genomics, (15):[PMID:10493829]
6.Garlisi, C G CG and 6 more authors.. (1999) The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.. European journal of immunology, [PMID:10540332]
7.Asojo, Oluwatoyin A OA, Boulègue, Cyril C, Hoover, David M DM, Lu, Wuyuan W and Lubkowski, Jacek J.. (2003) Structures of thymus and activation-regulated chemokine (TARC).. Acta crystallographica. Section D, Biological crystallography, [PMID:12832759]
8.Achuthan, Adrian A and 19 more authors.. (2016) Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.. The Journal of clinical investigation, (1):[PMID:27525438]
9.Hsu, Amy T AT and 6 more authors.. (2018) Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.. The Journal of biological chemistry, (20):[PMID:29871928]
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