Recombinant Human TARC/CCL17 Protein, >97% (SDS-PAGE and HPLC), high purity

Features and benefits
  • Expression System: E. coli
  • Accession #: Q92583
  • Protein Tag: No tag
  • Bioactivity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
  • Endotoxin Concentration: <0.01 EU/μg
Item Number
rp152075
Grouped product items
SKUSizeAvailabilityPrice Qty
rp152075-10μg
10μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$99.90
rp152075-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$369.90
rp152075-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$599.90
rp152075-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,999.90

Animal Free, >97% (SDS-PAGE and HPLC), Active, E. coli, No tag, 24-94 aa

Basic Description

Product NameRecombinant Human TARC/CCL17 Protein, >97% (SDS-PAGE and HPLC), high purity
SynonymsABCD-2; CC chemokine TARC; C-C motif chemokine 17; CCL17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TAR
GradeActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description

Purity
> 97% by SDS-PAGE and HPLC analyses.

Function
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Specifications & PurityActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥97%(SDS-PAGE&HPLC)
Purity>97% (SDS-PAGE and HPLC)
BioactivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
Endotoxin Concentration<0.01 EU/μg
Expression SystemE. coli
SpeciesHuman
Amino Acids24-94 aa
SequenceARGTNVGRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS
Protein TagNo tag
Accession #Q92583
Predicted molecular weight8.1kDa
SDS-PAGE8.1kDa

Images

Recombinant Human TARC/CCL17(rp152075)-Protein Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/mL.

Recombinant Human TARC/CCL17 Protein (rp152075)-SDS-PAGE
Recombinant Human TARC/CCL17 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 8.1 kDa under reducing conditionsand and 8.0-13.0kDa under non-reducing conditions.

Product Specifications

FormLyophilized
ReconstitutionReconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Stability And StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst

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Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ23F0600428Certificate of AnalysisMar 26, 2024 rp152075
ZJ23F0600429Certificate of AnalysisMar 26, 2024 rp152075
ZJ23F0600430Certificate of AnalysisMar 26, 2024 rp152075

Related Documents

References

1. Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A et al..  (1998)  Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor..  Eur J Immunol,  28  (2): (582-8).  [PMID:9521068]
2. Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D et al..  (2018)  Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia..  J Med Chem,  61  (17): (7671-7686).  [PMID:30106292]
3. Imai, T T and 5 more authors..  (1996)  Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector..  The Journal of biological chemistry,    (30):   [PMID:8702936]
4. Imai, T T and 5 more authors..  (1997)  The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4..  The Journal of biological chemistry,    (6):   [PMID:9169480]
5. Loftus, B J BJ and 18 more authors..  (1999)  Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q..  Genomics,    (15):   [PMID:10493829]
6. Garlisi, C G CG and 6 more authors..  (1999)  The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8..  European journal of immunology,      [PMID:10540332]
7. Asojo, Oluwatoyin A OA, Boulègue, Cyril C, Hoover, David M DM, Lu, Wuyuan W and Lubkowski, Jacek J..  (2003)  Structures of thymus and activation-regulated chemokine (TARC)..  Acta crystallographica. Section D, Biological crystallography,      [PMID:12832759]
8. Achuthan, Adrian A and 19 more authors..  (2016)  Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation..  The Journal of clinical investigation,    (1):   [PMID:27525438]
9. Hsu, Amy T AT and 6 more authors..  (2018)  Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages..  The Journal of biological chemistry,    (20):   [PMID:29871928]

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