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Recombinant Human TGF-beta RIII Protein

  • Animal Free
  • Carrier Free
  • ≥90%(SDS-PAGE)
Features and benefits
  • Expression System: HEK293
  • Protein Tag: C-His
  • Bioactivity: Testing in progress
  • Endotoxin Concentration: <1 EU/μg
Item Number
rp181281
Grouped product items
SKUSizeAvailabilityPrice Qty
rp181281-10μg (Trial Size)
Apply for free trial size(?)
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10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
rp181281-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$419.90
rp181281-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$669.90
rp181281-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,999.90

Animal Free, ≥90% (SDS-PAGE), 293F cell, C-His tag, 1-781 aa

Basic Description

Product NameRecombinant Human TGF-beta RIII Protein
GradeAnimal Free, Carrier Free
Product Description

Protein Function::
Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

Specifications & PurityAnimal Free, Carrier Free, ≥90%(SDS-PAGE)
BioactivityTesting in progress
Endotoxin Concentration<1 EU/μg
Expression SystemHEK293
Amino Acids1-781 aa
SequenceMTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITID
Protein TagC-His
Predicted molecular weight85.1 kDa
SDS-PAGE99.0-245.5 kDa, under reducing conditions; 99.0-245.5 kDa, under non-reducing conditions

Images

Recombinant Human TGF-beta RIII Protein (rp181281) - SDS-PAGE
2 μg/lane of Recombinant Human TGF-beta RIII Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 99.0-245.5 kDa conditions.

Product Specifications

ReconstitutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilu
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20°C for 1 year. Avoid freeze / thaw cycle.

Certificates

Certificate of Analysis(COA)

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1 results found

Lot NumberCertificate TypeDateItem
ZJ24R0700810Certificate of AnalysisJul 21, 2024 rp181281

Related Documents

Solution Calculators