Purity ＞95% SDS-PAGE. Function Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
17.0 kDa, under reducing conditions; 17.0 kDa, under non-reducing conditions.
Images
Recombinant Human TIGIT Protein - Protein Bioactivity Immobilized Human TIGIT (rp152378) at 1.5 μg/mL can bind Human CD155 with a linear range of 0.15 - 1.2 μg/mL.
Recombinant Human TIGIT Protein (rp152378) - SDS-PAGE 2.5 μg/lane of Recombinant Human TIGIT was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 17.0 kDa.
Recombinant Human TIGIT Protein (rp152378) - ELISA Immobilized Recombinant Human TIGIT Protein (rp152378) at 1.0 μg/mL can bind Domvanalimab (anti-TIGIT) (Ab182911) with the EC₅₀ of 15.97 ng/mL.
Recombinant Human TIGIT Protein (rp152378) - ELISA Immobilized Recombinant Human TIGIT Protein (rp152378) at 1.0 μg/mL can bind Ociperlimab (anti-TIGIT) (Ab182915) with the EC
₅₀
of 120.2 ng/mL.
Product Specifications
Form
Lyophilized
Reconstitution
Reconstitute in sterile H2O to a concentration of 0.1-0.5 mg/ml.
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at ﹣20~﹣80℃ for more than 1 year.
Certificates
Certificate of Analysis(COA)
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1.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H et al.. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.. Nat Immunol, 10 (1):(48-57). [PMID:19011627]
2.Stengel, Katharina F KF and 9 more authors.. (2012) Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.. Proceedings of the National Academy of Sciences of the United States of America, (3):[PMID:22421438]
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