| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| rp152616-10μg | 10μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 | |
| rp152616-25μg | 25μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 | |
| rp152616-100μg | 100μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $269.90 | |
| rp152616-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,279.90 |
Animal Free, >95% SDS-PAGE, Active, E.coli, No tag, Arg115-Gly281
| Product Name | Recombinant Human TRAIL Protein, ＞95% SDS-PAGE, high purity |
|---|---|
| Synonyms | Apo-2 ligand; APO2L; Apo-2Ltumor necrosis factor (ligand) family, member 10; APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta; CD253 antigen; CD253; Protein TRAIL; TL2; TNF-related apoptosis-inducing ligand; TNFSF10; TRAIL; TRAILT |
| Grade | ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High performance |
| Product Description | Purity >95% SDS-PAGE. Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Specifications & Purity | ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE) |
| Purity | ＞95% SDS-PAGE |
| Bioactivity | Measured by its ability to induce apoptosis in Jurkat cells (Human T Lymphocyte Cells). The ED₅₀ for this effect is typically <12ng/mL. |
| Endotoxin Concentration | ＜0.1 EU/μg |
| Expression System | E. coli |
| Species | Human |
| Amino Acids | 115-281 aa |
| Sequence | RERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG |
| Protein Tag | No tag |
| Protein Length | Protein fragment |
| Accession # | P50591 |
| Source | Recombinant |
| Predicted molecular weight | 19.5 kDa |
Recombinant Human TRAIL Protein (rp152616)-Protein Bioactivity
Measured by its ability to induce apoptosis in Jurkat cells (Human T Lymphocyte Cells). The ED₅₀ for this effect is typically <12ng/mL.
Recombinant Human TRAIL Protein (rp152616)-SDS-PAGE
3μg/lane of Recombinant Human TRAIL was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 17.7 kDa.
| Form | Lyophilized |
|---|---|
| Reconstitution | After receiving lyophilized powder protein, centrifuge first, and then redissolve with deionized water to the purposed concentration. |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Stable for 12 months from the date of receipt of the product under proper storage andhandling conditions. Avoid repeated freeze-thaw cycles. |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F0400113 | Certificate of Analysis | Apr 08, 2023 | rp152616 |
| ZJ23F0400112 | Certificate of Analysis | Apr 08, 2023 | rp152616 |
| ZJ23F0400111 | Certificate of Analysis | Apr 08, 2023 | rp152616 |
| ZJ23F0400110 | Certificate of Analysis | Apr 08, 2023 | rp152616 |
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| 2. Pitti, R M RM and 5 more authors.. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.. The Journal of biological chemistry, (31): [PMID:8663110] |
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| 5. Mongkolsapaya, J J and 6 more authors.. (1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.. Nature structural biology, [PMID:10542098] |
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| 8. Schnepple, David J DJ and 11 more authors.. (2011) Isolation of a TRAIL antagonist from the serum of HIV-infected patients.. The Journal of biological chemistry, (14): [PMID:21859711] |
| 9. Bordoli, Mattia R MR and 14 more authors.. (2014) A secreted tyrosine kinase acts in the extracellular environment.. Cell, (28): [PMID:25171405] |
| 10. Ramamurthy, Vidhyashankar V and 9 more authors.. (2015) The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.. Acta crystallographica. Section F, Structural biology communications, [PMID:26457518] |
