Recombinant Integrin beta 3 Antibody - Primary antibody, specific to Integrin beta 3, Mouse IgG1
Specifications & Purity
ExactAb™, Validated, Recombinant, 0.04 mg/mL
Host species
Mouse
Specificity
Integrin beta 3
Positive Control
IHC: Human spleen tissue.
Conjugation
Unconjugated
Grade
ExactAb™, Recombinant, Validated
Product Description
Mouse anti Human Integrin beta 3 Antibody, Recombinant (MyM1-CD61), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Product Properties
Isotype
Mouse IgG1
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
0.04 mg/mL
Storage Temp
Store at 2-8°C,Freeze prohibited
Shipped In
Wet ice
Stability And Storage
Store at 2-8°C long term (36 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant Integrin beta 3 Antibody (Ab110871) - IHC Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling Integrin beta 3 with Recombinant Integrin beta 3 Antibody (Ab110871) at 1/100 dilution. The section was incubated with Ab110871 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.