Recombinant; Rabbit anti Human KAT13D/CLOCK Antibody; WB; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab111747-10μl | 10μl | In stock | $66.90 | |
| Ab111747-50μl | 50μl | In stock | $199.90 | |
| Ab111747-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab111747-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
Recombinant; Rabbit anti Human KAT13D/CLOCK Antibody; WB; Unconjugated
| Product Name | Recombinant KAT13D/CLOCK Antibody - Primary antibody, specific to CLOCK, Rabbit IgG |
|---|---|
| Synonyms | BHLHE8; circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock (mouse) homolog; clock homolog (mouse); CLOCK; EC 2.3.1.48; hCLOCK; KAT13D; KIAA0334bHLHe8circadian locomoter output cycles kaput protein; bHLHe8 anti |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.4 mg/mL |
| Host species | Rabbit |
| Specificity | CLOCK |
| Immunogen | A synthetic peptide derived from human CLOCK (AA 145-180) |
| Positive Control | WB: A431 and NIH/3T3 cell lysates. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description | Rabbit anti Human KAT13D/CLOCK Antibody, Recombinant, could be used for WB and so on. |
| Isotype | Rabbit IgG |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant KAT13D/CLOCK Antibody (Ab111747) - Western Blot
All lanes: Recombinant KAT13D/CLOCK Antibody (Ab111747) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 95 kDa
Observed band size: 86 kDa
Exposure time: 30.0 s
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0505715 | Certificate of Analysis | May 16, 2024 | Ab111747 |
| ZJ24F0505714 | Certificate of Analysis | May 16, 2024 | Ab111747 |
| 1. Nagase, T T and 9 more authors.. (1997) Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA research : an international journal for rapid publication of reports on genes and genomes, (28): [PMID:9205841] |
| 2. Steeves, T D TD and 7 more authors.. (1999) Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei.. Genomics, (15): [PMID:10198158] |
| 3. Rutter, J J, Reick, M M, Wu, L C LC and McKnight, S L SL.. (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.. Science (New York, N.Y.), (20): [PMID:11441146] |
| 4. Curtis, Anne M AM and 7 more authors.. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.. The Journal of biological chemistry, (20): [PMID:14645221] |
| 5. Sato, Trey K TK and 9 more authors.. (2006) Feedback repression is required for mammalian circadian clock function.. Nature genetics, [PMID:16474406] |
| 6. Li, Ran R and 9 more authors.. (2008) CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.. Molecular and cellular biochemistry, [PMID:18587630] |
| 7. Ward, Sarah M SM, Fernando, Shanik J SJ, Hou, Tim Y TY and Duffield, Giles E GE.. (2010) The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.. The Journal of biological chemistry, (10): [PMID:20861012] |
| 8. Ye, Rui R, Selby, Christopher P CP, Ozturk, Nuri N, Annayev, Yunus Y and Sancar, Aziz A.. (2011) Biochemical analysis of the canonical model for the mammalian circadian clock.. The Journal of biological chemistry, (22): [PMID:21613214] |
| 9. Cotta-Ramusino, Cecilia C and 5 more authors.. (2011) A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.. Science (New York, N.Y.), (10): [PMID:21659603] |
| 10. DiTacchio, Luciano L and 6 more authors.. (2011) Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.. Science (New York, N.Y.), (30): [PMID:21960634] |
| 11. Charmandari, Evangelia E and 6 more authors.. (2011) Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man.. PloS one, [PMID:21980503] |
| 12. Tracey, C J CJ and 5 more authors.. (2012) Diurnal expression of the thrombopoietin gene is regulated by CLOCK.. Journal of thrombosis and haemostasis : JTH, [PMID:22284746] |
| 13. Li, S S and 9 more authors.. (2013) CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.. Oncogene, (10): [PMID:23160374] |
| 14. Wang, Zixi Z, Wu, Yaling Y, Li, Lanfen L and Su, Xiao-Dong XD.. (2013) Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.. Cell research, [PMID:23229515] |
| 15. Baeza-Raja, Bernat B and 7 more authors.. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (19): [PMID:23785138] |
| 16. Partch, Carrie L; Green, Carla B and Takahashi, Joseph S.. (2014) Molecular architecture of the mammalian circadian clock.. Trends in cell biology, [PMID:23916625] |
| 17. Al-Nuaimi, Yusur Y and 12 more authors.. (2014) A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock.. The Journal of investigative dermatology, [PMID:24005054] |
| 18. Kwak, Yongdo Y and 11 more authors.. (2013) Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.. The Journal of biological chemistry, (27): [PMID:24235147] |
| 19. Michael, Alicia K AK and 6 more authors.. (2015) Cancer/Testis Antigen PASD1 Silences the Circadian Clock.. Molecular cell, (4): [PMID:25936801] |
| 20. Lu, Yilu Y and 7 more authors.. (2017) Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.. Oncotarget, (15): [PMID:28903391] |
| 21. Lin, Ran R and 8 more authors.. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.. Molecular cell, (5): [PMID:28985504] |
| 22. Qu, Meng M, Duffy, Tomas T, Hirota, Tsuyoshi T and Kay, Steve A SA.. (2018) Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:30530698] |
